Drug related toxicity
Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 2 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Antiretroviral agent used for HIV
● 10 mg daily dose may be associated with hypophosphatemia, elevated creatinine level and Fanconi syndrome, due to reversible proximal tubular toxicity (Expert Opin Drug Saf 2011;10:809, Am J Ther 2011 Apr 23 [Epub ahead of print])
● Causes severe acute degenerative changes in proximal tubules, possibly mediated by focal deficiency of cytochrome C oxidase (Hum Pathol 2001;32:734)
● 47 year old man taking 10 mg/day adefovir for chronic Hepatitis B who developed Fanconi syndrome (Gut Liver 2010;4:389)
Electron microscopy description
● Proximal tubular mitochondria are enlarged, dysmorphic and disoriented with reduced cristae
End of Kidney non-tumor > Drug related toxicity > Adefovir nephrotoxicity
Ref Updated: 7/5/12
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