Kidney non-tumor - Adenovirus

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Kidney non-tumor

Infections / parasites

Adenovirus

Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 1 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● May cause necrotizing tubulointerstitial nephritis with hemorrhagic cystitis or prostate involvement
● Associated with bone marrow or other transplant recipients (Transpl Infect Dis 2011;13:174, Am J Kidney Dis 2012;59:886, Am J Transplant 2011;11:1308) and chemotherapy
● Adenovirus activation after immunosuppression can lead to systemic infection and may trigger rejection or early graft loss (Transpl Infect Dis 2011;13:168)
● Adenovirus is also used as a vector for gene therapy (Transpl Immunol 2011;25:34)

Micro description
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● Hemorrhage and necrosis
● Tubulitis with intranuclear inclusion bodies; either smudge cells, Cowdry A intranuclear inclusions or full-type intranuclear-containing cells (Hum Pathol 1991;22:1225)

Micro images
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Various images

Adenovirus immunoperoxidase stain

Electron microscopy description
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● Intranuclear crystalline arrays of 75-80 nm viral particles

End of Kidney non-tumor > Infections / parasites > Adenovirus

Ref Updated: 6/21/12

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