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Kidney non-tumor

Blood vessel disorders

Benign nephrosclerosis


Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 25 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Also called hypertensive nephrosclerosis
● Sclerosis of renal arterioles and small arteries, particularly afferent arterioles, due to hypertension
● Causes focal ischemia, moderate reduction in glomerular filtration rate, moderate proteinuria
● Causes end stage renal disease (QJM 2007;100:113); higher risk if African-American, severe hypertension, diabetes mellitus

Gross description
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● Mildly shrunken kidneys, cortical surface resembles leather

Gross images
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Various images

Micro description
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● Thickened and hyalinized vessel walls, hyaline deposition in arterioles, fibroelastic hyperplasia in lobular / arcuate arteries
● Tubular atrophy, interstitial fibrosis, periglomerular fibrosis and glomerulosclerosis
Hyaline arteriolosclerosis: outer wall thickened by PAS+ eosinophilic and homogenous material, with atrophy of smooth muscle cells in vessel wall and uniform basement membrane thickening; more common in afferent arteriole and vessels lacking an internal elastic lamina; associated with diabetes, hypertension and increasing age; IgM and C3 deposition

Micro images
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Various images

Virtual slides
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Arterio- and arteriolosclerosis

Electron microscopy images
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Thickened glomerular capillary walls

End of Kidney non-tumor > Blood vessel disorders > Benign nephrosclerosis

Ref Updated: 8/23/12


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