Blood vessel disorders
Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 25 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Also called hypertensive nephrosclerosis
● Sclerosis of renal arterioles and small arteries, particularly afferent arterioles, due to hypertension
● Causes focal ischemia, moderate reduction in glomerular filtration rate, moderate proteinuria
● Causes end stage renal disease (QJM 2007;100:113); higher risk if African-American, severe hypertension, diabetes mellitus
● Mildly shrunken kidneys, cortical surface resembles leather
● Thickened and hyalinized vessel walls, hyaline deposition in arterioles, fibroelastic hyperplasia in lobular / arcuate arteries
● Tubular atrophy, interstitial fibrosis, periglomerular fibrosis and glomerulosclerosis
● Hyaline arteriolosclerosis: outer wall thickened by PAS+ eosinophilic and homogenous material, with atrophy of smooth muscle cells in vessel wall and uniform basement membrane thickening; more common in afferent arteriole and vessels lacking an internal elastic lamina; associated with diabetes, hypertension and increasing age; IgM and C3 deposition
Arterio- and arteriolosclerosis
Electron microscopy images
Thickened glomerular capillary walls
End of Kidney non-tumor > Blood vessel disorders > Benign nephrosclerosis
Ref Updated: 8/23/12
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