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Kidney non-tumor

Primary glomerular diseases

Chronic glomerulonephritis


Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 4 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● An end stage disease, due to progression of various types of glomerulonephritis; occasionally no prior history of kidney disease (eMedicine)
Rates of progression: rapidly progressive (90%), post-streptococcal (1% kids, 5% adults), focal and segmental glomerulosclerosis (50-80%, rapid), membranous (50%), membranoproliferative (50%), IgA nephropathy (30-50%, slow)
● Paradoxically, nephrotic syndrome symptoms decrease as glomeruli disappear

Gross description
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● Symmetrically small kidneys with thin granular cortex and increased peripelvic fat

Gross images
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Due to hypertension


Chronic glomerulonephritis


Bilaterally small kidneys

Micro description
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● Glomerulosclerosis, tubular atrophy and thyroidization, interstitial fibrosis and lymphocytic inflammation
● Arterial and arteriolar sclerosis

Micro images
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End stage kidney with sclerotic glomeruli, tubular thyroidization, interstitial fibrosis and thickened arterial walls


Various images

Virtual slides
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Chronic glomerulonephritis

Videos
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By WashingtonDeceit

End of Kidney non-tumor > Primary glomerular diseases > Chronic glomerulonephritis

Ref Updated: 4/12/12


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