Primary glomerular diseases
Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 4 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● An end stage disease, due to progression of various types of glomerulonephritis; occasionally no prior history of kidney disease (eMedicine)
● Rates of progression: rapidly progressive (90%), post-streptococcal (1% kids, 5% adults), focal and segmental glomerulosclerosis (50-80%, rapid), membranous (50%), membranoproliferative (50%), IgA nephropathy (30-50%, slow)
● Paradoxically, nephrotic syndrome symptoms decrease as glomeruli disappear
● Symmetrically small kidneys with thin granular cortex and increased peripelvic fat
Due to hypertension
Bilaterally small kidneys
● Glomerulosclerosis, tubular atrophy and thyroidization, interstitial fibrosis and lymphocytic inflammation
● Arterial and arteriolar sclerosis
End stage kidney with sclerotic glomeruli, tubular thyroidization, interstitial fibrosis and thickened arterial walls
End of Kidney non-tumor > Primary glomerular diseases > Chronic glomerulonephritis
Ref Updated: 4/12/12
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