Kidney nontumor
Primary glomerular diseases
Chronic glomerulonephritis

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 14 September 2017, last major update September 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Chronic glomerulonephritis [title] "loattrfree full text"[sb]

Cite this page: Sangle, N. Chronic glomerulonephritis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneychronicgn.html. Accessed November 21st, 2017.
Definition / general
  • An end stage disease, due to progression of various types of glomerulonephritis; occasionally no prior history of kidney disease (eMedicine: Chronic Glomerulonephritis)
  • Rates of progression: rapidly progressive (90%), post streptococcal (1% children, 5% adults), focal and segmental glomerulosclerosis (50 - 80%, rapid), membranous (50%), membranoproliferative (50%), IgA nephropathy (30 - 50%, slow)
  • Paradoxically, nephrotic syndrome symptoms decrease as glomeruli disappear
Gross description
  • Symmetrically small kidneys with thin granular cortex and increased peripelvic fat
Gross images

Images hosted on other servers:

Due to hypertension

Chronic glomerulonephritis

Bilaterally small kidneys

Microscopic (histologic) description
  • Glomerulosclerosis, tubular atrophy and thyroidization, interstitial fibrosis and lymphocytic inflammation
  • Arterial and arteriolar sclerosis
Microscopic (histologic) images

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End stage kidney with sclerotic glomeruli, tubular thyroidization, interstitial fibrosis and thickened arterial walls

Various images

Videos

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