Kidney nontumor
Primary glomerular diseases
Diffuse mesangial hypercellularity with nephrotic syndrome

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 15 September 2017, last major update March 2012

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PubMed Search: Diffuse mesangial hypercellularity with nephrotic syndrome

Cite this page: Sangle, N. Diffuse mesangial hypercellularity with nephrotic syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneydiffusemesangial.html. Accessed October 22nd, 2017.
Definition / general
  • 2 - 10% of renal biopsies from patients with idiopathic nephrotic syndrome
  • Presents with nephrotic syndrome, more likely to have hypertension and hematuria
  • In adults, represents a heterogeneous group with different clinical courses (Ren Fail 2009;31:192, Nephrol Dial Transplant 2000;15:981)
  • Associated with steroid resistant or steroid dependent minimal change glomerulopathy, focal and segmental glomerulosclerosis
  • Note: minimal change disease, diffuse mesangial hypercellularity and focal and segmental glomerulosclerosis may be a continuum of the same disease
Microscopic (histologic) description
  • Mild mesangial hypercellularity, patent capillary lumens and normal basement membrane thickness
Microscopic (histologic) images

Images hosted on other servers:

Left to right: mild, moderate disease

H&E

Immunofluorescence
  • Nonspecific; IgM and variable C3
Electron microscopy description
  • Obliteration of foot processes, sparse mesangial deposits