Kidney nontumor
Other primary glomerular diseases
Diffuse mesangial hypercellularity with nephrotic syndrome

Topic Completed: 5 March 2012

Minor changes: 12 February 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Diffuse mesangial hypercellularity with nephrotic syndrome

Nikhil Sangle, M.D.
Page views in 2019: 1,152
Page views in 2020 to date: 553
Cite this page: Sangle N. Diffuse mesangial hypercellularity with nephrotic syndrome. website. Accessed June 1st, 2020.
Definition / general
  • 2 - 10% of renal biopsies from patients with idiopathic nephrotic syndrome
  • Presents with nephrotic syndrome, more likely to have hypertension and hematuria
  • In adults, represents a heterogeneous group with different clinical courses (Ren Fail 2009;31:192, Nephrol Dial Transplant 2000;15:981)
  • Associated with steroid resistant or steroid dependent minimal change glomerulopathy, focal and segmental glomerulosclerosis
  • Note: minimal change disease, diffuse mesangial hypercellularity and focal and segmental glomerulosclerosis may be a continuum of the same disease
Microscopic (histologic) description
  • Mild mesangial hypercellularity, patent capillary lumens and normal basement membrane thickness
Microscopic (histologic) images

Images hosted on other servers:

Mild disease


Immunofluorescence description
  • Nonspecific; IgM and variable C3
Electron microscopy description
  • Obliteration of foot processes, sparse mesangial deposits
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