Kidney non-tumor - Diffuse mesangial hypercellularity with nephrotic syndrome

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Kidney non-tumor

Primary glomerular diseases

Diffuse mesangial hypercellularity with nephrotic syndrome

Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 15 April 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● 2-10% of renal biopsies from patients with idiopathic nephrotic syndrome
● Presents with nephrotic syndrome, more likely to have hypertension and hematuria
● In adults, represents a heterogeneous group with different clinical courses (Ren Fail 2009;31:192, Nephrol Dial Transplant 2000;15:981)
● Associated with steroid resistant or steroid dependent minimal change glomerulopathy, focal and segmental glomerulosclerosis
● Note: minimal change disease, diffuse mesangial hypercellularity and focal and segmental glomerulosclerosis may be a continuum of the same disease

Micro description
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● Mild mesangial hypercellularity, patent capillary lumens and normal basement membrane thickness

Micro images
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Left to right: mild, moderate, severe disease

Various images

Immunofluoresence
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● Non-specific; IgM and variable C3

Electron microscopy description
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● Obliteration of foot processes, sparse mesangial deposits

Differential diagnosis
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● Differentiate using immunofluorescence and electron microscopy:

● Acute postinfectious glomerulonephritis-resolving phase
● C1q nephropathy
● IgA nephropathy
● Mesangial proliferative lupus nephritis
● Mild membranoproliferative glomerulonephritis

End of Kidney non-tumor > Primary glomerular diseases > Diffuse mesangial hypercellularity with nephrotic syndrome

Ref Updated: 4/13/12

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