Kidney non-tumor - Glomerular tip lesion

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Kidney non-tumor

Primary glomerular diseases

Glomerular tip lesion

Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 24 April 2012, last major update April 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Segmental glomerular lesions at the tubular opening, or tip changes, are found in the renal biopsies of adults in many disorders
● In focal and sclerosing glomerulosclerosis, appears to have similar response to therapy as classic disease (Nephrol Dial Transplant 2011;26:2215)
● Associated with childhood minimal change nephropathy (Pediatr Nephrol 2008;23:1281)

Micro description
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● Sclerosis only in portion of glomerulus opposite the hilus, forming an adhesion near the opening of Bowman’s space into proximal tubule
● Capillary lumina of sclerotic loops may be obliterated by swollen endothelial cells with vacuoles and foam cells

Micro images
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Glomerular tip lesion

Immunofluorescence
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● Segmental IgM and C3

Electron microscopy description
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● Lesions resemble FSGS, except for their location at the tubular pole

Electron microscopy images
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Severe effacement of foot processes overlying patent capillaries

End of Kidney non-tumor > Primary glomerular diseases > Glomerular tip lesion

Ref Updated: 4/20/12

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