Kidney nontumor
Other primary glomerular diseases
Glomerular tip lesion


Topic Completed: 2 April 2012

Revised: 26 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Glomerular tip lesion

Nikhil Sangle, M.D.
Page views in 2018: 326
Page views in 2019 to date: 291
Cite this page: Sangle N. Glomerular tip lesion. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneyglomerulartiplesion.html. Accessed December 10th, 2019.
Definition / general
  • Segmental glomerular lesions at the tubular opening or tip changes are found in the renal biopsies of adults in many disorders
  • In focal and sclerosing glomerulosclerosis, appears to have similar response to therapy as classic disease (Nephrol Dial Transplant 2011;26:2215)
  • Associated with childhood minimal change nephropathy (Pediatr Nephrol 2008;23:1281)
Microscopic (histologic) description
  • Sclerosis only in portion of glomerulus opposite the hilus, forming an adhesion near the opening of Bowman space into proximal tubule
  • Capillary lumina of sclerotic loops may be obliterated by swollen endothelial cells with vacuoles and foam cells
Microscopic (histologic) images

Images hosted on other servers:


Glomerular tip lesion

Immunofluorescence description
  • Segmental IgM and C3
Electron microscopy description
  • Lesions resemble FSGS except for their location at the tubular pole
Electron microscopy images

Images hosted on other servers:

Severe effacement of
foot processes overlying
patent capillaries

Back to top