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Kidney non-tumor

Drug related toxicity

Gold therapy


Reviewer: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 2 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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Gold salts may cause interstitial nephritis or nephrotic syndrome with gold deposits present within tubular epithelium, interstitial macrophages and free within renal interstitium
● Gold treatment may be continued for short periods under close supervision despite moderate proteinuria without causing permanent renal damage (Br J Rheumatol 1989;28:53)

Case reports
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● Due to gold salts for rheumatoid arthritis (Arch Pathol Lab Med 1983;107:258, Arch Pathol Lab Med 1977;101:635)

Treatment
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● Cessation of gold therapy

Immunofluorescence
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● May have IgG or C3 deposits in granular pattern in glomerular basement membrane, due to unknown immune complex (Arch Pathol Lab Med 1981;105:373)

End of Kidney non-tumor > Drug related toxicity > Gold therapy

Ref Updated: 7/10/12


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