Kidney non-tumor - Hantavirus

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Kidney non-tumor

Infections / parasites

Hantavirus

Reviewer: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 1 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rodent RNA virus that causes hemorrhagic fever with renal and pulmonary syndrome (Arch Pathol Lab Med 2003;127:30)

Clinical features
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● Often presents with fever (acute flu-like febrile illness), thrombocytopenia (with hemorrhage), acute renal injury (sudden and extreme albuminuria, renal failure, Int Urol Nephrol 2012;44:1185)
● Renal disease typically only occurs in non-US cases, severity depends on causative agent (severe - Dobrava-Belgrade and Hantaan; moderate - Seoul; mild - Puumala virus, Nephrology (Carlton) 2010;15:340, Nephrol Dial Transplant 2010;25:2997)
● Overall mortality rate is 7%
● Proteinuria and increased systolic blood pressure persist up to 6 years after acute episode (Nephron Clin Pract 2009;112:c115)
● Caused significant mortality during Korean War (formerly known as Korean hemorrhagic fever)
● Infects glomeruli and tubules; infection causes breakdown of cell-to-cell contacts (J Virol 2011;85:9811)

Case reports
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● 30 year old man with uncommonly severe infection with Puumala strain (J Am Soc Nephrol 2008;19:1653)
● 31 year old man in Tbilisi, Georgia (Emerg Infect Dis 2009;15:1489)

Micro images
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Various images

Immunohistochemistry

End of Kidney non-tumor > Infections / parasites > Hantavirus

Ref Updated: 6/29/12

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