Kidney nontumor
Infections / parasites

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 21 March 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Hantavirus [title] kidney pathology

Cite this page: Sangle, N. Hantavirus. website. Accessed October 23rd, 2018.
Definition / general
Clinical features
  • Often presents with fever (acute flu like febrile illness), thrombocytopenia (with hemorrhage), acute renal injury (sudden and extreme albuminuria, renal failure, Int Urol Nephrol 2012;44:1185)
  • Renal disease typically only occurs in non US cases, severity depends on causative agent (Nephrology (Carlton) 2010;15:340, Nephrol Dial Transplant 2010;25:2997)
    • Severe: Dobrava-Belgrade and Hantaan
    • Moderate: Seoul
    • Mild: Puumala virus
  • Overall mortality rate is 7%
  • Proteinuria and increased systolic blood pressure persist up to 6 years after acute episode (Nephron Clin Pract 2009;112:c115)
  • Caused significant mortality during Korean War (formerly known as Korean hemorrhagic fever)
  • Infects glomeruli and tubules; infection causes breakdown of cell to cell contacts (J Virol 2011;85:9811)
Case reports
Microscopic (histologic) images

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