Kidney nontumor
Viral infections

Topic Completed: 3 September 2012

Minor changes: 18 February 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Hantavirus [title] kidney pathology

Nikhil Sangle, M.D.
Page views in 2019: 81
Page views in 2020 to date: 68
Cite this page: Sangle N. Hantavirus. website. Accessed May 28th, 2020.
Definition / general
Clinical features
  • Often presents with fever (acute flu-like febrile illness), thrombocytopenia (with hemorrhage), acute renal injury (sudden and extreme albuminuria, renal failure, Int Urol Nephrol 2012;44:1185)
  • Renal disease typically only occurs in non U.S. cases, severity depends on causative agent (Nephrology (Carlton) 2010;15:340, Nephrol Dial Transplant 2010;25:2997)
    • Severe: Dobrava-Belgrade and Hantaan
    • Moderate: Seoul
    • Mild: Puumala virus
  • Overall mortality rate is 7%
  • Proteinuria and increased systolic blood pressure persist up to 6 years after acute episode (Nephron Clin Pract 2009;112:c115)
  • Caused significant mortality during Korean War (formerly known as Korean hemorrhagic fever)
  • Infects glomeruli and tubules; infection causes breakdown of cell to cell contacts (J Virol 2011;85:9811)
Case reports
Microscopic (histologic) images

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