Kidney nontumor
Monoclonal immunoglobulin disease
Heavy chain deposition disease

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 13 November 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Heavy chain deposition disease [title] kidney pathology

Cite this page: Sangle, N. Heavy chain deposition disease. website. Accessed November 15th, 2018.
Definition / general
  • Lymphoplasmacytic neoplasm that produces an abnormally truncated immunoglobulin heavy chain protein that lacks associated light chains (eMedicine: Gamma Heavy Chain Disease [Accessed 17 January 2018])
  • Less common than light chain deposition disease
  • May have milder hematological disorders than in light chain deposition disease (Clin Nephrol 2009;71:9)
  • Associated with various lymphoproliferative disorders, but usually has features overlapping with cases previously reported as "vaguely nodular, polymorphous" lymphoplasmacytic lymphoma (Am J Surg Pathol 2012;36:534)
Case reports
  • 51 year old man with linear deposits of gamma 4 heavy chains along glomerular, tubular and vascular basement membrane and in mesangial regions (Mod Pathol 1994;7:874)
  • 68 year old woman with gamma 1 heavy chain disease (Intern Med 2010;49:1411)
  • Monotypic mu heavy chain mesangial deposits causing nodular glomerulosclerosis in woman without evident hematopoietic malignancy (Hum Pathol 2000;31:122)
  • Follow up biopsy post chemotherapy showed remarkable diminution of both nodular glomerular lesions and IgG heavy chain deposits (Clin Nephrol 2008;69:383)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Immunofluorescence description
  • IgG heavy chains along glomerular, tubular and vascular basement membranes and in mesangium
  • No light chain deposition