Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Kidney non-tumor

Associated with systemic conditions

Heavy chain deposition disease


Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 27 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Lymphoplasmacytic neoplasm that produces an abnormally truncated immunoglobulin heavy-chain protein that lacks associated light chains (eMedicine)
● Less common than light chain deposition disease
● May have milder hematological disorders than in light chain deposition disease (Clin Nephrol 2009;71:9)
● Associated with various lymphoproliferative disorders, but usually has features overlapping with cases previously reported as "vaguely nodular, polymorphous" lymphoplasmacytic lymphoma (Am J Surg Pathol 2012;36:534)

Case reports
=========================================================================

● 51 year old man with linear deposits of gamma 4 heavy chains along glomerular, tubular and vascular basement membrane and in mesangial regions (Mod Pathol 1994;7:874)
● 68 year old woman with gamma 1 heavy chain disease (Intern Med 2010;49:1411)
● Monotypic mu heavy chain mesangial deposits causing nodular glomerulosclerosis in woman without evident hematopoietic malignancy (Hum Pathol 2000;31:122)
● Follow up biopsy post-chemotherapy showed remarkable diminution of both nodular glomerular lesions and IgG heavy-chain deposits (Clin Nephrol 2008;69:383)

Micro images
=========================================================================


       
Various images

Immunofluorescence
=========================================================================

● IgG heavy chains along glomerular, tubular and vascular basement membranes and in mesangium
● No light chain deposition

Electron microscopy images
=========================================================================



Subendothelial electron-dense deposits and mesangial expansion

End of Kidney non-tumor > Associated with systemic conditions > Heavy chain deposition disease

Ref Updated: 7/27/12


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).