Blood vessel disorders
Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 25 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Renal hemosiderosis due to hemolytic anemia is rare cause of renal failure (Am J Pathol 1966;48:409, Indian J Pathol Microbiol 2011;54:379)
● Defined as histologic equivalent of secondary iron overload, usually due to hemosiderin from hemoglobin breakdown, which may be focal
● Typically free serum hemoglobin is bound to haptoglobin, but in severe cases, haptoglobin is overwhelmed, free hemoglobin is filtered by kidney and deposited in proximal convoluted tubules, which may cause renal failure
● 52 year old man with unexplained renal failure (Case of Week #235)
● Hemosiderin is golden yellow to brown, granular cellular pigment
H&E and iron stains
Electron microscopy images
Groups of dark granules likely made up of heme proteins (white arrows) and autophagolytic lysosomal vacuoles (black arrows) containing mitochondria
End of Kidney non-tumor > Blood vessel disorders > Hemosiderosis
Ref Updated: 8/24/12
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