Kidney nontumor
Blood vessel disorders

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 21 March 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Kidney hemosiderosis [title]

Cite this page: Sangle, N. Hemosiderosis. website. Accessed October 15th, 2018.
Definition / general
  • Renal hemosiderosis due to hemolytic anemia is rare cause of renal failure (Am J Pathol 1966;48:409, Indian J Pathol Microbiol 2011;54:379)
  • Defined as histologic equivalent of secondary iron overload, usually due to hemosiderin from hemoglobin breakdown, which may be focal
  • Typically free serum hemoglobin is bound to haptoglobin, but in severe cases, haptoglobin is overwhelmed, free hemoglobin is filtered by kidney and deposited in proximal convoluted tubules, which may cause renal failure
Case reports
Microscopic (histologic) description
  • Hemosiderin is golden yellow to brown, granular cellular pigment
Microscopic (histologic) images

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H&E and iron stains

Electron microscopy images

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Groups of dark granules likely made
up of heme proteins (white arrows)
and autophagolytic lysosomal vacuoles
(black arrows) containing mitochondria