Kidney nontumor
IgA related glomerulonephritis
Henoch-Schönlein purpura

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 12 November 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Henoch-Schonlein purpura [title] kidney pathology

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Cite this page: Sangle, N. Henoch-Schonlein purpura. website. Accessed January 21st, 2019.
Definition / general
  • Purpuric skin lesions on extensor arms and legs and buttocks
  • Also abdominal pain, vomiting, GI bleeding, arthralgias, hematuria, proteinuria and nephrotic syndrome
  • Due to systemic small vessel leukocytoclastic vasculitis
  • Most common systemic vasculitis in children
  • Also called anaphylactoid purpura
Clinical features
Case reports
Microscopic (histologic) description
  • Leukocytoclastic vasculitis of small vessels due to deposition of IgA immune complexes
  • Diffuse proliferation of mesangial cells and matrix without significant involvement of capillary walls or lumina
  • Also segmental necrotizing lesions (50%), endocapillary proliferation (13%), cellular crescents, glomerular acute and chronic inflammatory infiltrate

  • Glomerular sclerosis, tubular loss, interstitial fibrosis and hyaline arteriolosclerosis

  • Hemorrhage and necrotizing vasculitis in dermal small vessels, which contain IgA
  • Vasculitis is present in other organs but usually NOT kidney
Microscopic (histologic) images

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Various images

Immunofluorescence description
  • IgA deposition in mesangium, resembling IgA nephropathy
  • Variable IgG, IgM, C3 and properdin
Immunofluorescence images

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purpura nephritis
Electron microscopy description
  • Mesangial deposits, may extend into subendothelial areas
  • May have subepithelial deposits