Kidney nontumor
Primary glomerular diseases
Idiopathic nodular glomerulosclerosis

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 20 September 2017, last major update May 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Idiopathic nodular glomerulosclerosis

Cite this page: Sangle, N. Idiopathic nodular glomerulosclerosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneyidiopathicnodgs.html. Accessed October 19th, 2017.
Definition / general
  • Resembles nodular diabetic glomerulosclerosis (Kimmelstiel-Wilson changes) but in nondiabetic patients
  • Mean age 68 years, 74% white and 78% men (Hum Pathol 2002;33:826)
  • Typically presents with renal insufficiency (83%, mean serum creatinine of 2.4 mg/dL), proteinuria > 3 g/day (70%) and nephrotic syndrome (22%)
  • Associated with hypertension (96%), smoking (91%, mean 53 pack years), hypercholesterolemia (90%) and extrarenal vascular disease (44%, Hum Pathol 2002;33:826); also increased body mass index / overweight (Hum Pathol 2008;39:1771)
  • A diagnosis of exclusion
  • Poor prognostic factors for end stage renal disease: continued smoking, lack of angiotensin II blockage and degree of arteriosclerosis
Microscopic (histologic) description
  • Prominent diffuse and nodular mesangial sclerosis, glomerular basement membrane thickening, arteriosclerosis and arteriolosclerosis
  • Also neovascularization of glomeruli
Microscopic (histologic) images

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Idiopathic nodular glomerulosclerosis

Positive stains
  • CD34 highlights increased number of vascular channels within glomeruli compared with normal controls
Differential diagnosis

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