Kidney non-tumor - Karyomegalic nephropathy

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Kidney non-tumor

Tubular and interstitial diseases

Karyomegalic nephropathy

Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 25 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Marked enlargement and hyperchromatic nuclei (karyomegaly) in tubular cells with associated interstitial fibrosis surrounding atrophic tubules
● Due to mutations in FAN1 (Nat Genet 2012;44:910)
● Karyomegaly may also be present within GI tract, lungs, vessels
● Unknown etiology - may be genetic or associated with ochra toxin

Micro description
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● Focal marked enlargement of tubular cells with prominent nuclei and nucleoli
● Chronic interstitial nephritis, normal and sclerotic glomeruli

Micro images
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Striking nuclear enlargement and hyperchromasia of tubular cell nucleis

PathoPics: various images

Cytology description
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● Urine cytology contains large pleomorphic cells, resembling carcinoma (Diagn Cytopathol 2007;35:179)

Electron microscopy images
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PathoPics: various images

Differential diagnosis
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● Lead toxicity

End of Kidney non-tumor > Tubular and interstitial diseases > Karyomegalic nephropathy

Ref Updated: 8/17/12

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