Kidney nontumor
Tubular and interstitial diseases
Karyomegalic nephropathy

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 6 February 2018, last major update December 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Karyomegaly nephropathy

Cite this page: Sangle, N. Karyomegalic nephropathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneykaryomegalic.html. Accessed February 19th, 2018.
Definition / general
  • Marked enlargement and hyperchromatic nuclei (karyomegaly) in tubular cells with associated interstitial fibrosis surrounding atrophic tubules
  • Due to mutations in FAN1 (Nat Genet 2012;44:910)
  • Karyomegaly may also be present within GI tract, lungs, vessels
  • Unknown etiology - may be genetic or associated with ochra toxin
Microscopic (histologic) description
  • Focal marked enlargement of tubular cells with prominent nuclei and nucleoli
  • Chronic interstitial nephritis, normal and sclerotic glomeruli
Microscopic (histologic) images

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Striking nuclear enlargement and
hyperchromasia of tubular cell nucleis


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PathoPics: various images

Cytology description
Electron microscopy images

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PathoPics: various images

Differential diagnosis