Kidney nontumor
Genetic
Karyomegalic interstitial nephritis


Topic Completed: 3 December 2012

Minor changes: 17 February 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Karyomegalic interstitial nephritis

Nikhil Sangle, M.D.
Page views in 2019: 149
Page views in 2020 to date: 88
Cite this page: Sangle N. Karyomegalic interstitial nephritis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneykaryomegalic.html. Accessed May 28th, 2020.
Definition / general
  • Marked enlargement and hyperchromatic nuclei (karyomegaly) in tubular cells with associated interstitial fibrosis surrounding atrophic tubules
  • Due to mutations in FAN1 (Nat Genet 2012;44:910)
  • Karyomegaly may also be present within GI tract, lungs, vessels
  • Unknown etiology - may be genetic or associated with ochra toxin
Microscopic (histologic) description
  • Focal marked enlargement of tubular cells with prominent nuclei and nucleoli
  • Chronic interstitial nephritis, normal and sclerotic glomeruli
Microscopic (histologic) images

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Striking nuclear enlargement and
hyperchromasia of tubular cell nucleis


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Various images

Cytology description
Electron microscopy images

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Various images

Differential diagnosis
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