Kidney nontumor
Toxins
Lead nephropathy


Topic Completed: 3 December 2012

Revised: 12 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Lead nephropathy [title]

Nikhil Sangle, M.D.
Page views in 2018: 175
Page views in 2019 to date: 97
Cite this page: Sangle N. Lead nephropathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneylead.html. Accessed June 24th, 2019.
Definition / general
  • Kidney is main route for lead removal from body; lead is absorbed by proximal tubular cells, binds to specific proteins; with acute lead nephrotoxicity in dose-response relationship (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2010;28:170), these lead-protein complexes are seen as intracellular inclusions (eMedicine: Lead nephropathy [Accessed 28 December 2017])
  • Due to occupational (electric storage battery makers, foundrymen, jewelers, painters, welders) or environmental causes (children eating lead pain, water in lead pipe systems, lead earthenware, moonshine liquor)
  • Lead exposure damages central and peripheral nervous system, GI tract and kidney
Microscopic (histologic) description
  • Tubular atrophy and interstitial fibrosis
  • Tubular inclusions are eosinophilic and intranuclear or cytoplasmic, acid-fast and red with Giemsa stain
  • Arteriolar disease similar to nephrosclerosis
  • Tubules disappear in chronic disease; no inflammation
Microscopic (histologic) images

Images hosted on other servers:
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Nonspecific tubular
atrophy and interstitial
fibrosis, absence of
interstitial infiltrate
Missing Image

Lead inclusions in
nucleus of tubular cells
Electron microscopy description
  • Inclusions are lead-protein complex that appear as compact cores surrounded by loose meshwork of fibrils
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