Kidney nontumor
Genetic and metabolic tubular disease
Nephrocalcinosis


Topic Completed: 3 December 2012

Revised: 12 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Nephrocalcinosis [title]

Nikhil Sangle, M.D.
Page views in 2018: 592
Page views in 2019 to date: 437
Cite this page: Sangle N. Nephrocalcinosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneynephrocalcinosis.html. Accessed August 23rd, 2019.
Definition / general
Causes
  • Conditions associated with chronic hypercalcemia, including primary hyperparathyroidism, myeloma or other malignancy; also distal renal tubular acidosis, hypercalciuria due to chronic furosemide use in premature infants (Hum Pathol 2000;31:1363), milk alkali syndrome, oral sodium phosphate as bowel preparation (Hum Pathol 2004;35:675), sarcoidosis, vitamin D intoxication
Treatment
  • Reduce urinary saturation of calcium by increasing fluid intake, crystallization inhibitors, disease-specific medication, (Kidney Int 2011;80:1278)
Microscopic (histologic) description
  • Diffuse tubular injury with atrophy, interstitial fibrosis and abundant tubular deposition of calcium phosphate
  • Over time, glomerulosclerosis and vascular disease
Microscopic (histologic) images

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Various images

Electron microscopy images

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Calcium deposits (arrows)
with glomerular capillary
basement membrane
and mesangium
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