Kidney nontumor
Genetic and metabolic tubular disease

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 26 November 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Nephrocalcinosis [title]

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Cite this page: Sangle, N. Nephrocalcinosis. website. Accessed February 15th, 2019.
Definition / general
  • Conditions associated with chronic hypercalcemia, including primary hyperparathyroidism, myeloma or other malignancy; also distal renal tubular acidosis, hypercalciuria due to chronic furosemide use in premature infants (Hum Pathol 2000;31:1363), milk alkali syndrome, oral sodium phosphate as bowel preparation (Hum Pathol 2004;35:675), sarcoidosis, vitamin D intoxication
  • Reduce urinary saturation of calcium by increasing fluid intake, crystallization inhibitors, disease-specific medication, (Kidney Int 2011;80:1278)
Microscopic (histologic) description
  • Diffuse tubular injury with atrophy, interstitial fibrosis and abundant tubular deposition of calcium phosphate
  • Over time, glomerulosclerosis and vascular disease
Microscopic (histologic) images

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Various images

Electron microscopy images

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Calcium deposits (arrows)
with glomerular capillary
basement membrane
and mesangium