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Kidney non-tumor

Drug related toxicity

NSAID associated nephropathy


Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 3 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

See also Analgesic nephropathy

General
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● NSAIDs rarely cause acute renal failure due to inhibition of vasodilatory prostaglandins
● May cause an acute hypersensitivity interstitial nephritis, acute interstitial nephritis and minimal change disease together, or membranous glomerulonephritis

Clinical features
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● Particularly affects newborns and elderly (Eur Rev Med Pharmacol Sci 2011;15:1461, Am J Med 2007;120:280e1)
● Increased risk of acute renal failure in volume depleted children (Arch Dis Child 2007;92:524, Ned Tijdschr Geneeskd 2006;150:1861)

Micro images
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Minimal change glomerulopathy


Renal cortical necrosis in mildly dehydrated 13 year old girl receiving diclofenac sodium for Crohn's disease

End of Kidney non-tumor > Drug related toxicity > NSAID associated nephropathy

Ref Updated: 7/13/12


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