Kidney non-tumor - Oxycodone nephropathy

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Kidney non-tumor

Drug related toxicity

Oxycodone nephropathy

Reviewer: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 3 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Intravenous injection of suppositories containing oxycodone may cause granulomatous glomerulonephritis and subsequent renal failure (Hum Pathol 1998;29:1246)
● May also cause widespread tubulointerstitial involvement, with fibrillar deposits in glomeruli and tubular basement membranes (Hum Pathol 2002;33:783)

Clinical features
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● Oxycodone can accumulate during chronic renal failure (South Med J 2007;100:212)
● Elderly may have higher levels due to altered pharmacokinetics (Drugs Aging 2011;28:41)

Positive stains
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● PAS

Negative stains
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● Congo red, silver

End of Kidney non-tumor > Drug related toxicity > Oxycodone nephropathy

Ref Updated: 7/13/12

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