Kidney nontumor
General
Physiology


Topic Completed: 2 April 2012

Revised: 1 October 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Physiology of kidney "loattrfree full text"[sb] non-tumor

Nikhil Sangle, M.D.
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Cite this page: Sangle N. Physiology. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneyphysiology.html. Accessed October 15th, 2019.
Definition / general
  • Filters 1700 L of blood to 1 L of urine per day
  • Excretes metabolic waste; regulates water, salt, and pH
  • Secretes renin, prostaglandins and erythropoietin
  • Nephron production ceases at birth, there are 1.3 million/kidney
  • Renal intercalated cells may regulate pH through expression of soluble adenylate cyclase, a sensor that detects luminal bicarbonate and activates the vacuolar proton pumping ATPase via cAMP (Am J Physiol Cell Physiol 2012;302:C1421)
  • Nephron: glomerulus filters blood, ultrafiltrate enters Bowman’s space, filtrate enters proximal convoluted tubule, to pars recta of proximal tubule, to thin descending limp of loop of Henle, to thick ascending limb of loop of Henle, to macula densa (adjacent to glomerulus), to distal convoluted tubule, to collecting tubule, to collecting duct of Bellini and to calyx (Wikipedia: Renal physiology)
  • Clearance: amount of plasma cleared of a substance per minute to appear in urine
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