Physiology of kidney
Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 11 April 2012, last major update April 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Filters 1700L of blood to 1L of urine per day
● Excretes metabolic waste; regulates water, salt, and pH
● Secretes renin, prostaglandins and erythropoietin
● Nephron production ceases at birth, are 1.3 million / kidney
● Renal intercalated cells may regulate pH through expression of soluble adenylate cyclase, a sensor that detects luminal bicarbonate and activates the vacuolar proton-pumping ATPase via cAMP (Am J Physiol Cell Physiol 2012 Mar 28 [Epub ahead of print])
● Nephron: glomerulus filters blood, ultrafiltrate enters Bowmanís space, filtrate enters proximal convoluted tubule, to pars recta of proximal tubule, to thin descending limp of loop of Henle, to thick ascending limb of loop of Henle, to macula densa (adjacent to glomerulus), to distal convoluted tubule, to collecting tubule, to collecting duct of Bellini and to calyx (Wikipedia)
● Clearance: amount of plasma cleared of a substance per minute to appear in urine
Details on physiology
End of Kidney non-tumor > Physiology of kidney
Ref Updated: 4/6/12
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