Kidney nontumor
Associated with systemic conditions
Preeclampsia


Topic Completed: 3 December 2012

Minor changes: 13 February 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Preeclampsia [title] kidney

Nikhil Sangle, M.D.
Page views in 2019: 550
Page views in 2020 to date: 230
Cite this page: Sangle N. Preeclampsia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneypreeclampsia.html. Accessed May 28th, 2020.
Definition / general
Clinical features
  • 5 - 7% of first pregnancies, usually affects women at extremes of reproductive age
  • In subsequent pregnancies, associated with multiple births, fetal hydrops
  • Called eclampsia if convulsions develop
  • May be caused by primary endothelial cell injury causing local intravascular coagulation
  • Good prognosis; glomerular changes and blood pressure return to normal within weeks of delivery
Microscopic (histologic) description
  • Enlarged, swollen and bloodless glomeruli with capillary lumina obliterated by swollen endothelial cells
  • No / mild hypercellularity; may have herniation of capillary tuft into proximal tubule (tufting)
  • Rare crescent formation in severe cases; normal afferent arterioles
Microscopic (histologic) images

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Various images

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Glomerular endotheliosis

Immunofluorescence description
  • Fibrinogen deposits, occasionally IgM
Electron microscopy description
  • Lysosomal-like, single membrane lined vacuoles within cytoplasm of endothelium and mesangial cells
  • Some vacuoles contain bland lipids or have myelin-like figures
Electron microscopy images

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Marked endothelial cell swelling
and vacuolization and extensive
epithelial foot-process effacement
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Swollen endothelial cell with epithelial
foot processes intact (A), swollen
endothelial and mesangial cells showing
prominent vacuolization on capillary lumina
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