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Kidney non-tumor

Primary glomerular diseases

Glomerular disease-general


Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 10 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Glomerulonephritis: inflammation of glomerulus
Glomerulopathy: any disorder affecting glomerulus
Primary: kidney is only or predominant organ involved
● Changes can be diffuse (all glomeruli) or focal; global (entire glomerulus) or segmental (part of glomerulus) or mesangial
● Minimal change disease, diffuse mesangial hypercellularity and focal and segmental glomerulosclerosis may be a continuum of the same disease
● EGFR pathway may be new therapeutic target in glomerular disease (Nephrol Dial Transplant 2012;27:1297)

Micro description
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Hypercellularity: due to cellular proliferation (mesangial, endothelial, parietal epithelial cells); white blood cells (acute and chronic) or crescents (white blood cells and epithelial cells)
Basement membrane thickening is highlighted by PAS stain and electron microscopy; EM also shows electron-dense deposits (usually immune complexes) in or adjacent to basement membrane (subepithelial is most common)
Hyalinization and sclerosis of glomeruli are the end result of glomerular damage from various causes

Micro images
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Hypercellularity

Additional references
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Cleveland Clinic

End of Kidney non-tumor > Primary glomerular diseases > Glomerular disease-general

Ref Updated: 4/9/12


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