Kidney non-tumor - Glomerular disease-general

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Kidney non-tumor

Primary glomerular diseases

Glomerular disease-general

Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 10 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Glomerulonephritis: inflammation of glomerulus
● Glomerulopathy: any disorder affecting glomerulus
● Primary: kidney is only or predominant organ involved
● Changes can be diffuse (all glomeruli) or focal; global (entire glomerulus) or segmental (part of glomerulus) or mesangial
● Minimal change disease, diffuse mesangial hypercellularity and focal and segmental glomerulosclerosis may be a continuum of the same disease
● EGFR pathway may be new therapeutic target in glomerular disease (Nephrol Dial Transplant 2012;27:1297)

Micro description
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● Hypercellularity: due to cellular proliferation (mesangial, endothelial, parietal epithelial cells); white blood cells (acute and chronic) or crescents (white blood cells and epithelial cells)
● Basement membrane thickening is highlighted by PAS stain and electron microscopy; EM also shows electron-dense deposits (usually immune complexes) in or adjacent to basement membrane (subepithelial is most common)
● Hyalinization and sclerosis of glomeruli are the end result of glomerular damage from various causes

Micro images
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Hypercellularity

Additional references
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● Cleveland Clinic

End of Kidney non-tumor > Primary glomerular diseases > Glomerular disease-general

Ref Updated: 4/9/12

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