Kidney nontumor
Primary glomerular diseases
Glomerular disease - general

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 13 September 2017, last major update September 2012

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PubMed Search: kidney (glomerular disease [title]) "loattrfree full text"[sb]

Cite this page: Sangle, N. Glomerular disease - general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneyprimaryglomgen.html. Accessed October 24th, 2017.
Definition / general
  • Glomerulonephritis: inflammation of glomerulus
  • Glomerulopathy: any disorder affecting glomerulus
  • Primary: kidney is only or predominant organ involved
  • Changes can be diffuse (all glomeruli) or focal; global (entire glomerulus) or segmental (part of glomerulus) or mesangial
  • Minimal change disease, diffuse mesangial hypercellularity and focal and segmental glomerulosclerosis may be a continuum of the same disease
  • EGFR pathway may be new therapeutic target in glomerular disease (Nephrol Dial Transplant 2012;27:1297)
Microscopic (histologic) description
  • Hypercellularity: due to cellular proliferation (mesangial, endothelial, parietal epithelial cells); white blood cells (acute and chronic) or crescents (white blood cells and epithelial cells)
  • Basement membrane thickening is highlighted by PAS stain and electron microscopy; EM also shows electron dense deposits (usually immune complexes) in or adjacent to basement membrane (subepithelial is most common)
  • Hyalinization and sclerosis of glomeruli are the end result of glomerular damage from various causes
Microscopic (histologic) images

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Hypercellularity