Kidney nontumor
Other primary glomerular diseases
Rapidly progressive (crescentic) glomerulonephritis TYPE 2

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 20 November 2018, last major update February 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

Related topic: Rapidly progressive (crescentic) glomerulonephritis
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Cite this page: Sangle, N. Rapidly progressive (crescentic) glomerulonephritis TYPE 2. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneyrpgntype2.html. Accessed December 10th, 2019.
Definition / general
TYPE 2: Immune complex crescentic glomerulonephritis (35%)

  • Immune complex deposition with complement activation due to postinfectious glomerulonephritis, types I and II membranoproliferative glomerulonephritis, cryoglobulinemic glomerulonephritis, SLE, IgA nephropathy, Henoch-Schönlein purpura and idiopathic
  • Usually children
  • Must treat underlying disease; plasmapheresis NOT helpful (in contast to anti GBM glomerulonephritis)
Microscopic (histologic) description
  • Depends on underlying glomerular disease
  • Mild to moderate necrosis of glomerular segments adjacent to crescents, less than types 1 or 3
  • Various combinations of capillary wall thickening and endocapillary cell proliferation
Immunofluorescence description
  • Lumpy bumpy for IgG and C3 (like postinfectious)
Electron microscopy description
  • Immune complex deposits as subepithelial humps or mesangial deposits, fibrin at glomerular basement membrane breaks
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