Kidney non-tumor - Sickle cell disease nephropathy

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Kidney non-tumor

Blood vessel disorders

Sickle cell disease nephropathy

Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 25 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Sickle cell trait or disease causes hematuria, decreased concentrating ability
● May be due to ischemia in hypertonic, hypoxic renal medulla due to plugging of vessels in vasa recta
● Mild proteinuria in 30%

Gross images
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Necrotizing papillitis

Micro description
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● Patchy papillary necrosis
● Occlusion of glomeruli by sickled cells
● Extensive congestion and sickling in peritubular capillaries

Micro images
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Sickle cell nephropathy

Case report of collapsing glomerulopathy

Electron microscopy images
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Sickle red cells inside glomerular capillary loop

End of Kidney non-tumor > Blood vessel disorders > Sickle cell disease nephropathy

Ref Updated: 8/28/12

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