Kidney nontumor
Other vascular disorders
Sickle cell disease nephropathy


Topic Completed: 3 December 2012

Minor changes: 14 February 2020

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PubMed Search: Sickle cell disease [title] nephropathy

Nikhil Sangle, M.D.
Page views in 2019: 251
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Cite this page: Sangle N. Sickle cell disease nephropathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneysicklecell.html. Accessed May 29th, 2020.
Definition / general
  • Sickle cell trait or disease causes hematuria, decreased concentrating ability
  • May be due to ischemia in hypertonic, hypoxic renal medulla due to plugging of vessels in vasa recta
  • Mild proteinuria in 30%
Microscopic (histologic) description
  • Patchy papillary necrosis
  • Occlusion of glomeruli by sickled cells
  • Extensive congestion and sickling in peritubular capillaries
Microscopic (histologic) images

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Case report of collapsing glomerulopathy

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