Kidney nontumor
Other vascular disorders
Sickle cell disease nephropathy


Topic Completed: 3 December 2012

Revised: 12 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Sickle cell disease [title] nephropathy
Page views in 2018: 376
Page views in 2019 to date: 106
Cite this page: Sangle N. Sickle cell disease nephropathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneysicklecell.html. Accessed April 22nd, 2019.
Definition / general
  • Sickle cell trait or disease causes hematuria, decreased concentrating ability
  • May be due to ischemia in hypertonic, hypoxic renal medulla due to plugging of vessels in vasa recta
  • Mild proteinuria in 30%
Gross images

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Necrotizing papillitis

Microscopic (histologic) description
  • Patchy papillary necrosis
  • Occlusion of glomeruli by sickled cells
  • Extensive congestion and sickling in peritubular capillaries
Microscopic (histologic) images

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Case report of collapsing glomerulopathy

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