Kidney nontumor
Other vascular disorders
Sickle cell disease nephropathy

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 21 November 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Sickle cell disease [title] nephropathy

Page views in 2018: 376
Page views in 2019 to date: 55
Cite this page: Sangle, N. Sickle cell disease nephropathy. website. Accessed February 17th, 2019.
Definition / general
  • Sickle cell trait or disease causes hematuria, decreased concentrating ability
  • May be due to ischemia in hypertonic, hypoxic renal medulla due to plugging of vessels in vasa recta
  • Mild proteinuria in 30%
Gross images

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Necrotizing papillitis

Microscopic (histologic) description
  • Patchy papillary necrosis
  • Occlusion of glomeruli by sickled cells
  • Extensive congestion and sickling in peritubular capillaries
Microscopic (histologic) images

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Case report of collapsing glomerulopathy