Kidney nontumor
Bacterial infections
Tuberculosis


Topic Completed: 7 January 2013

Revised: 12 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Tuberculosis [title] kidney pathology

Nikhil Sangle, M.D.
Page views in 2019: 3,072
Page views in 2020 to date: 112
Cite this page: Sangle N. Tuberculosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytb.html. Accessed January 18th, 2020.
Definition / general
Clinical features
  • Renal involvement may be indolent, may not become apparent until 20+ years from detection of primary infection
  • Urogenital TB is associated with unilateral nonfunctioning kidney in 27% of cases, with renal failure present in 7% (Int J Urol 2008;15:827)
  • In chronic kidney disease of all causes, one study from India demonstrated a 4% incidence of TB, which was usually tuberculin skin test negative (Clin Nephrol 2007;67:217)
  • In immunocompromised patients, urogenital TB usually has systemic symptoms, dissemination, multiple renal foci (Int Urol Nephrol 2009;41:327)
Case reports
Radiology images

Images hosted on other servers:

Renal tuberculosis

Gross description
  • Multiple cavities filled with yellow friable necrotic material
Gross images

Images hosted on PathOut server:

Renal tuberculosis



Images hosted on other servers:

Renal tuberculosis

Microscopic (histologic) description
  • Extensive caseous necrosis, with occasional granulomas composed of epithelioid cells and Langhans giant cells with surrounding lymphocytes
  • Very early granulomas might not show caseation
  • The interface of viable cells and caseous necrosis is where acid fast bacilli (AFB) are most found
Microscopic (histologic) images

Images hosted on PathOut servers:

Various images



Images hosted on other servers:

Various images

Miliary tuberculosis - kidney

Differential diagnosis
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