Cite this page: Sangle N. Tubular and interstitial disease-general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytubulargeneral.html. Accessed August 15th, 2020.
Definition / general
- Primary tubulointerstitial disease (nephritis) lacks significant glomerular or vascular injury; causes 20 - 40% of cases of end stage renal disease (eMedicine: Tubulointerstitial Nephritis [Accessed 03 January 2018])
- Secondary tubulointerstitial nephritis is due to glomerular disease, systemic or vascular disorders
- Tubulointerstitial disease may be acute (interstitial edema, neutrophils, focal tubular necrosis) or chronic (mononuclear inflammation, interstitial fibrosis, tubular atrophy)
- Symptoms: inability to concentrate urine (polyuria, nocturia), salt wasting and diminished ability to excrete acids (metabolic acidosis)
- Causes: infections, jejunoileal bypass (Arch Pathol Lab Med 1980;104:112) metabolic disease, toxins, tumors, vascular diseases
- IgG4 staining recommended to identify subset with IgG4 related disease (Clin Nephrol 2011;76:440)