Kidney nontumor
Other tubular and interstitial disease

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 26 November 2018, last major update February 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Tubular and interstitial [title] diseases

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Cite this page: Sangle, N. Tubular and interstitial diseases general. website. Accessed January 23rd, 2019.
Definition / general
  • Primary tubulointerstitial disease (nephritis) lacks significant glomerular or vascular injury; causes 20 - 40% of cases of end stage renal disease (eMedicine: Tubulointerstitial Nephritis [Accessed 03 January 2018])
  • Secondary tubulointerstitial nephritis is due to glomerular disease, systemic or vascular disorders
  • Tubulointerstitial disease may be acute (interstitial edema, neutrophils, focal tubular necrosis) or chronic (mononuclear inflammation, interstitial fibrosis, tubular atrophy)
  • Symptoms: inability to concentrate urine (polyuria, nocturia), salt wasting and diminished ability to excrete acids (metabolic acidosis)
  • Causes: infections, jejunoileal bypass (Arch Pathol Lab Med 1980;104:112) metabolic disease, toxins, tumors, vascular diseases
  • IgG4 staining recommended to identify subset with IgG4 related disease (Clin Nephrol 2011;76:440)
Case reports
Microscopic (histologic) images

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Acute interstitial nephritis -
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Interstitial inflammation

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Interstitial inflammation with eosinophils

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Tubulointerstitial nephritis