Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Kidney non-tumor

Tubular and interstitial diseases

General


Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 13 February 2014, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Primary tubulointerstitial disease (nephritis) lacks significant glomerular or vascular injury; causes 20-40% of cases of end stage renal disease (eMedicine)
● Secondary tubulointerstitial nephritis is due to glomerular disease, systemic or vascular disorders
● Tubulointerstitial disease may be acute (interstitial edema, neutrophils, focal tubular necrosis) or chronic (mononuclear inflammation, interstitial fibrosis, tubular atrophy)
● Symptoms: inability to concentrate urine (polyuria, nocturia), salt wasting and diminished ability to excrete acids (metabolic acidosis)
● Causes: infections, jejunoileal bypass (Arch Pathol Lab Med 1980;104:112) metabolic disease, toxins, tumors, vascular diseases
● IgG4 staining recommended to identify subset with IgG4 related disease (Clin Nephrol 2011;76:440)

Case reports
=========================================================================

● 12 year old boy with Crohn's disease (Nat Clin Pract Nephrol 2008;4:693)
● 20 year old man with idiopathic tubulointerstitial nephritis and uveitis / TINU syndrome (Nephrol Dial Transplant 2008;23:771)

Micro images
=========================================================================



Tubulointerstitial nephritis


Idiopathic hypocomplementemic immune-complex-mediated tubulointerstitial nephritis

Acute interstitial nephritis -

Interstitial inflammation


Interstitial inflammation with eosinophils

Virtual slides
=========================================================================



Interstitial nephritis

Electron microscopy images
=========================================================================



Idiopathic hypocomplementemic immune-complex-mediated tubulointerstitial nephritis

End of Kidney non-tumor > Tubular and interstitial diseases > General

Ref Updated: 8/16/12


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).