Kidney nontumor
Tubulointestitial disease
Other tubular and interstitial disease
Tubular and interstitial disease-general

Topic Completed: 3 November 2014

Minor changes: 30 June 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Tubular and interstitial [title] diseases

Nikhil Sangle, M.D.
Page views in 2019: 2,311
Page views in 2020 to date: 1,755
Cite this page: Sangle N. Tubular and interstitial disease-general. website. Accessed August 15th, 2020.
Definition / general
  • Primary tubulointerstitial disease (nephritis) lacks significant glomerular or vascular injury; causes 20 - 40% of cases of end stage renal disease (eMedicine: Tubulointerstitial Nephritis [Accessed 03 January 2018])
  • Secondary tubulointerstitial nephritis is due to glomerular disease, systemic or vascular disorders
  • Tubulointerstitial disease may be acute (interstitial edema, neutrophils, focal tubular necrosis) or chronic (mononuclear inflammation, interstitial fibrosis, tubular atrophy)
  • Symptoms: inability to concentrate urine (polyuria, nocturia), salt wasting and diminished ability to excrete acids (metabolic acidosis)
  • Causes: infections, jejunoileal bypass (Arch Pathol Lab Med 1980;104:112) metabolic disease, toxins, tumors, vascular diseases
  • IgG4 staining recommended to identify subset with IgG4 related disease (Clin Nephrol 2011;76:440)
Case reports
Microscopic (histologic) images

Acute interstitial nephritis
Missing Image Missing Image Missing Image

Interstitial inflammation

Missing Image

Interstitial inflammation with eosinophils

Images hosted on other servers:
Missing Image

Tubulointerstitial nephritis

Back to top