Kidney nontumor
Tubular and interstitial diseases
General

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 11 July 2018, last major update February 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Tubular and interstitial [title] diseases

Cite this page: Sangle, N. Tubular and interstitial diseases general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytubulargeneral.html. Accessed September 25th, 2018.
Definition / general
  • Primary tubulointerstitial disease (nephritis) lacks significant glomerular or vascular injury; causes 20 - 40% of cases of end stage renal disease (eMedicine: Tubulointerstitial Nephritis [Accessed 03 January 2018])
  • Secondary tubulointerstitial nephritis is due to glomerular disease, systemic or vascular disorders
  • Tubulointerstitial disease may be acute (interstitial edema, neutrophils, focal tubular necrosis) or chronic (mononuclear inflammation, interstitial fibrosis, tubular atrophy)
  • Symptoms: inability to concentrate urine (polyuria, nocturia), salt wasting and diminished ability to excrete acids (metabolic acidosis)
  • Causes: infections, jejunoileal bypass (Arch Pathol Lab Med 1980;104:112) metabolic disease, toxins, tumors, vascular diseases
  • IgG4 staining recommended to identify subset with IgG4 related disease (Clin Nephrol 2011;76:440)
Case reports
Microscopic (histologic) images

Images hosted on Pathout server:

Acute interstitial nephritis -
Missing Image Missing Image Missing Image

Interstitial inflammation

Missing Image

Interstitial inflammation with eosinophils


Images hosted on other servers:
Missing Image

Tubulointerstitial nephritis