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Kidney tumor - cysts, children, adult benign

Benign (usually) adult tumors

2004 WHO classification of renal tumors


Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 13 January 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Classification - general
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● Classification is based on cytology, tissue characteristics (Thoenes, Storkel & Rumpelt, Pathol Res Pract 1986;181:125) and cytogenetics
● Use of "granular cell variant" of renal cell carcinoma (Urology 2007;69:452) and "sarcomatoid carcinoma" (Cancer 1997;80:987) are discouraged
● "Sarcomatoid” carcinomas should be classified as high grade carcinoma of originating type or as unclassified
Possible new features to incorporate: VEGF expression (Lab Invest 2008;88:962), gene expression (ScientificWorldJournal 2006;6:2505)
● Heidelberg classification used previously (J Pathol 1997;183:131)

Kidney tumors in infants and children (WHO)
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Nephroblastic tumors:
● Nephroblastoma
     ● Favorable histology
     ● Unfavorable histology (diffuse / focal anaplasia)
● Nephrogenic rests and nephroblastomatosis
● Cystic nephroma and cystic partially differentiated nephroblastoma
● Metanephric tumors
     ● Metanephric adenoma
     ● Metanephric adenofibroma
     ● Metanephric stromal tumor

Mesoblastic nephroma:
● Classic
● Cellular
● Mixed

Clear cell carcinoma
Rhabdoid tumor of kidney

Renal epithelial tumors of childhood:
● Papillary renal cell carcinoma
● Renal medullary carcinoma
● Translocation associated RCC (Xp11.2 / t(6;11) translocations)

Rare tumors:
● Ossifying renal tumor of infancy
● Angiomyolipoma

Renal tumors and tumor-like conditions of adults (WHO)
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Renal cell carcinoma
Renal cortical adenoma

Metanephric tumors:
● Metanephric adenoma
● Metanephric adenofibroma
● Metanephric stromal tumor
● Metanephric adenosarcoma

Oncocytoma

Rare tumors with epithelial / parenchymal differentiation:
● Carcinoid tumor
● Small cell carcinoma
● Primitive neuroectodermal tumor
● Juxtaglomerular cell tumor
● Teratoma
● Nephroblastoma and other “pediatric” renal tumors
● Multilocular cyst (cystic nephroma)
● Mixed epithelial and stromal tumor
● Spiradenocylindroma

Mesenchymal tumors:
● Angiomyolipoma
● Epithelioid angiomyolipoma
● Medullary fibroma
● Leiomyoma
● Lipoma
● Hemangioma
● Lymphangioma
● Other benign mesenchymal tumors
● Leiomyosarcoma
● Liposarcoma
● Solitary fibrous tumor
● Hemangiopericytoma
● Fibrosarcoma and malignant fibrous histiocytoma
● Rhabdomyosarcoma
● Angiosarcoma
● Osteosarcoma
● Synovial sarcoma
● Other malignant mesenchymal tumors

Lymphoid tumors
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● Plasmacytoma

Metastatic tumors and tumor-like lesions
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● Metastatic tumors
● Xanthogranulomatous pyelonephritis
● Inflammatory myofibroblastic pseudotumor
● Perirenal and sinus cysts

Additional references
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Eble: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs (3rd Ed, 2004)

End of Kidney tumor - cysts, children, adult benign > Benign (usually) adult tumors > 2004 WHO classification of renal tumors


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