Kidney tumor - cysts, children, adult benign

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Kidney tumor - cysts, children, adult benign

Benign (usually) adult tumors

Glomus tumor

Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 26 January 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Tumor of modified perivascular smooth muscle cells
● Variants include glomus tumor, glomangioma (more vascular) and glomangiomyoma (has elongated smooth muscle cells)

Clinical features
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● Usually benign behavior
● Most common site is distal extremities, rare in visceral organs or kidney

Case reports
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● 53 year old man (Case of Week #187)
● 55 year old woman with renal glomangioma (Arch Pathol Lab Med 2005;129:1172)
● 62 year old man #1 (Int J Surg Pathol 2011;19:393), #2 (UPMC Case #602)
● Three patients with solid glomus tumor, glomangioma and glomangiomyoma (Am J Surg Pathol 2007;31:585)

Micro description
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● Well circumscribed nodule composed of sheets and nests of round and somewhat cohesive cells with abundant pale cytoplasm, smooth nuclear borders and occasional nucleoli
● Cells may appear epithelioid
● Histologic appearance depends on vascular cell to glomus cell ratio, their differentiation and the amount and composition of the stroma
● Though rare, tumors with malignant potential have been described
● Poor prognostic factors include large size, deep location, infiltrative pattern, mitoses, necrosis and nuclear pleomorphism

Micro images
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Glomus tumor-various images

Glomangioma-various images

Positive stains
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● Smooth muscle actin, vimentin and type 4 collagen

Negative stains
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● Negative for endothelial, epithelial, melanocytic and neuroendocrine markers, although some of these markers may stain vessels and entrapped renal epithelium
● Also negative for desmin

Electron microscopy description
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● Modified smooth muscle cells (thin microfilaments, dense bodies)

Additional references
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● eMedicine

End of Kidney tumor - cysts, children, adult benign > Benign (usually) adult tumors > Glomus tumor

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