Kidney tumor
Childhood neoplasms

Author: Mandolin Ziadie, M.D.

Revised: 19 April 2018, last major update December 2011

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Neuroblastoma kidney [title]

Page views in 2018: 1,309
Page views in 2019 to date: 85
Cite this page: Ziadie, M.S. Neuroblastoma. website. Accessed January 18th, 2019.
Definition / general
  • Small blue cell tumor
  • May be a primary renal tumor or a metastasis from adrenal / retroperitoneal primary (See Adrenal gland chapter)
Clinical features
  • Usually diagnosed in adolescents / young adults
  • Laboratory studies include elevated serum / urine catecholamines
  • Propensity for metastasis for bone / orbit
  • Poor prognosis associated with N-myc amplification or 1p-
Case reports
Gross description
  • Soft fleshy cut surface with necrosis and hemorrhage
  • Possible calcifications
Microscopic (histologic) description
  • Small round blue cell tumor with Homer-Wright pseudorosettes and neuropil
  • Microcalcification and necrosis are common
Positive stains
  • Catecholamines (90%), NSE and S100
Electron microscopy description
  • Neurofilaments, neurotubules, synaptic vessels and dense core granules
Differential diagnosis
  • Wilms tumor: has blastema, epithelioid structures and fibroblast-like stroma