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Kidney tumor - cysts, children, adult benign

Childhood neoplasms

Neuroblastoma


Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 7 November 2014, last major update December 2011
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.

General
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● Small blue cell tumor
● May be a primary renal tumor or a metastasis from adrenal / retroperitoneal primary (See Adrenal gland chapter)

Clinical features
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● Usually diagnosed in adolescents / young adults
● Laboratory studies include elevated serum / urine catecholamines
● Propensity for metastasis fo bone / orbit
● Poor prognosis associated with N-myc amplification or 1p-

Case reports
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● Kidney invasion through capsule (J Pediatr Surg 1994;29:930)
● Primary kidney tumor in adults (J Urol 1987;137:966)

Gross description
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● Soft fleshy cut surface with necrosis and hemorrhage
● Possible calcifications

Micro description
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● Small round blue cell tumor with Homer-Wright pseudorosettes and neuropil
● Microcalcification and necrosis are common

Positive stains
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● Catecholamines (90%), NSE and S100

E.M. description
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● Neurofilaments, neurotubules, synaptic vessels and dense core granules

Differential diagnosis
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Wilms’ tumor: has blastema, epithelioid structures and fibroblast-like stroma

End of Kidney tumor - cysts, children, adult benign > Childhood neoplasms > Neuroblastoma


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