Kidney tumor
Childhood neoplasms

Topic Completed: 1 December 2011

Revised: 12 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Neuroblastoma kidney [title]

Mandolin S. Ziadie, M.D.
Page views in 2018: 1,309
Page views in 2019 to date: 1,340
Cite this page: Ziadie MS. Neuroblastoma. website. Accessed October 19th, 2019.
Definition / general
  • Small blue cell tumor
  • May be a primary renal tumor or a metastasis from adrenal / retroperitoneal primary (See Adrenal gland chapter)
Clinical features
  • Usually diagnosed in adolescents / young adults
  • Laboratory studies include elevated serum / urine catecholamines
  • Propensity for metastasis for bone / orbit
  • Poor prognosis associated with N-myc amplification or 1p-
Case reports
Gross description
  • Soft fleshy cut surface with necrosis and hemorrhage
  • Possible calcifications
Microscopic (histologic) description
  • Small round blue cell tumor with Homer-Wright pseudorosettes and neuropil
  • Microcalcification and necrosis are common
Positive stains
  • Catecholamines (90%), NSE and S100
Electron microscopy description
  • Neurofilaments, neurotubules, synaptic vessels and dense core granules
Differential diagnosis
  • Wilms tumor: has blastema, epithelioid structures and fibroblast-like stroma
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