Kidney tumor - adult malignancies
Adult renal cell carcinoma
Adult papillary renal tumor with oncocytic cells

Author: Nicole K. Andeen, M.D. (see Authors page)

Revised: 30 January 2017, last major update June 2015

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PubMed Search: Adult papillary renal tumor oncocytic cells

Cite this page: Adult papillary renal tumor with oncocytic cells . PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantadultpapillaryrenal.html. Accessed February 24th, 2017.
Definition / General
Terminology
Sites
  • Kidney
Clinical Features
Case Reports
Treatment
  • Resection
Clinical Images

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CT findings

Gross Description
  • Median 3 cm, well circumscribed, no extrarenal extension
Gross Images

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Papillary renal cell carcinoma with oncocytic cells

Micro Description
  • Thin, nonfibrotic papillae lined by single layer of oncocytic cells
  • Low grade, round, regular, nonoverlapping nuclei with central nucleolus (Am J Surg Pathol 2005;29:1576)
  • Abundant granular eosinophilic cytoplasm
  • Variable foamy macrophages within papillae
  • Hemosiderin accumulation, focal necrosis
  • May have luminal orientation of tumor nuclei (Pathol Int 2009;59:137) or solid oncocytoma-like areas (Ann Diagn Pathol 2006;10:133)
Micro Images

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Papillary type 1 oncocytic renal cell carcinoma, c/o Drs. Nicole Andeen and Maria Tretiakova

Phagocytosis of tumor cells

Racemase, CD10, vimentin, MET

Positive Stains
Negative Stains
Electron Microscopy Description
Molecular / Cytogenetics Description
Differential Diagnosis
  • Oncocytoma: no papillary architecture, no necrosis; negative for vimentin, CD10, AMACR, CK7; positive for c-kit / CD117
  • Papillary adenoma with oncocytic cells: less than 5 mm (size criteria)
  • Papillary type 1 tumors: single layer of cells lining papillae but with pale basophilic cytoplasm, strong diffuse CK7 positivity
  • Papillary type 2 tumors: higher nuclear grade, crowded and pseudostratified nuclei