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Kidney tumor - adult malignancies

Adult renal cell carcinoma

Adult papillary renal tumor with oncocytic cells


Reviewers: Sean Williamson, M.D. (see Reviewers page)
Revised: 5 December 2014, last major update June 2012
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.

General
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● May be same entity as oncocytic papillary renal cell carcinoma with inverted nuclear pattern (Pathol Int 2009;59:137)

Epidemiology
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● Usually male, median age 71 years

Gross description
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● Median 3 cm, well circumscribed, no extrarenal extension

Micro description
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● Thin, nonfibrotic papillae lined by single layer of oncocytic cells with finely granular eosinophilic cytoplasm, round regular nonoverlapping nuclei, central nucleolus (usually grade 2)
● Usually focal necrosis (Am J Surg Pathol 2005;29:1576)

Positive stains
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● AMACR, vimentin, CD10, variable RCCma and CK7

Cytogenetic description
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● No +7, no +17 in one study, but all tumors had +7 and +17 in another study (Hum Pathol 2008;39:96)

Differential diagnosis
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Oncocytoma: no papillary architecture, no necrosis
Papillary type 2 tumors: no oncocytic cells

End of Kidney tumor - adult malignancies > Adult renal cell carcinoma > Adult papillary renal tumor with oncocytic cells


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