Kidney tumor
Adult renal cell carcinoma
Adult papillary renal tumor with oncocytic cells

Topic Completed: 1 June 2015

Revised: 4 March 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Adult papillary renal tumor oncocytic cells
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Cite this page: Andeen NK, Tretiakova M. Adult papillary renal tumor with oncocytic cells . website. Accessed May 23rd, 2019.
Definition / general
  • Kidney
Clinical features
Case reports
  • Resection
Clinical images

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CT findings

Gross description
  • Median 3 cm, well circumscribed, no extrarenal extension
Gross images

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Papillary renal cell carcinoma with oncocytic cells

Microscopic (histologic) description
  • Thin, nonfibrotic papillae lined by single layer of oncocytic cells
  • Low grade, round, regular, nonoverlapping nuclei with central nucleolus (Am J Surg Pathol 2005;29:1576)
  • Abundant granular eosinophilic cytoplasm
  • Variable foamy macrophages within papillae
  • Hemosiderin accumulation, focal necrosis
  • May have luminal orientation of tumor nuclei (Pathol Int 2009;59:137) or solid oncocytoma-like areas (Ann Diagn Pathol 2006;10:133)
Microscopic (histologic) images

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Papillary type 1 oncocytic renal cell carcinoma, c/o Drs. Nicole Andeen and Maria Tretiakova

Phagocytosis of tumor cells

Racemase, CD10, vimentin, MET

Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
Differential diagnosis
  • Oncocytoma: no papillary architecture, no necrosis; negative for vimentin, CD10, AMACR, CK7; positive for c-kit / CD117
  • Papillary adenoma with oncocytic cells: 15 mm (1.5 cm) or less (size criteria)
  • Papillary type 1 tumors: single layer of cells lining papillae but with pale basophilic cytoplasm, strong diffuse CK7 positivity
  • Papillary type 2 tumors: higher nuclear grade, crowded and pseudostratified nuclei
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