Kidney tumor
Papillary: Oncocytic
Oncocytic papillary renal cell carcinoma


Topic Completed: 1 June 2015

Revised: 3 June 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Adult papillary renal tumor oncocytic cells

Nicole K. Andeen, M.D.
Maria Tretiakova, M.D., Ph.D.
Page views in 2018: 3,819
Page views in 2019 to date: 2,378
Cite this page: Andeen NK, Tretiakova M. Oncocytic papillary renal cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantadultpapillaryrenal.html. Accessed July 18th, 2019.
Definition / general
Terminology
Sites
  • Kidney
Clinical features
Case reports
Treatment
  • Resection
Clinical images

Images hosted on other servers:

CT findings

Gross description
  • Median 3 cm, well circumscribed, no extrarenal extension
Gross images

Contributed by Nicole K. Andeen, M.D.

Papillary renal cell carcinoma with oncocytic cells

Microscopic (histologic) description
  • Thin, nonfibrotic papillae lined by single layer of oncocytic cells
  • Low grade, round, regular, nonoverlapping nuclei with central nucleolus (Am J Surg Pathol 2005;29:1576)
  • Abundant granular eosinophilic cytoplasm
  • Variable foamy macrophages within papillae
  • Hemosiderin accumulation, focal necrosis
  • May have luminal orientation of tumor nuclei (Pathol Int 2009;59:137) or solid oncocytoma-like areas (Ann Diagn Pathol 2006;10:133)
Microscopic (histologic) images

Contributed by Nicole K. Andeen, M.D. and Maria Tretiakova, M.D., Ph.D.

Papillary type 1 oncocytic renal cell carcinoma



Contributed by Semir Vranić, M.D., Ph.D., University of Sarajevo (Bosnia)

Oncocytic "variant" of papillary renal cell carcinoma



Images hosted on other servers:

Racemase, CD10, vimentin, MET

Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
Differential diagnosis
  • Oncocytoma: no papillary architecture, no necrosis; negative for vimentin, CD10, AMACR, CK7; positive for c-kit / CD117
  • Papillary adenoma with oncocytic cells: 15 mm (1.5 cm) or less (size criteria)
  • Papillary type 1 tumors: single layer of cells lining papillae but with pale basophilic cytoplasm, strong diffuse CK7 positivity
  • Papillary type 2 tumors: higher nuclear grade, crowded and pseudostratified nuclei
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