Kidney tumor
Other adult malignancies

Author: Sean R. Williamson, M.D.

Revised: 19 April 2018, last major update June 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Angiosarcoma kidney

Page views in 2018: 558
Page views in 2019 to date: 82
Cite this page: Williamson, S.R. Angiosarcoma. website. Accessed February 19th, 2019.
Definition / general
  • Malignant vascular tumor with anastomosing vascular spaces lined by atypical endothelial cells
  • Very rare as primary kidney tumor (< 50 cases reported), almost all men, more often left sided, presenting with hematuria, flank pain or palpable mass; metastasis to the kidney from a primary site elsewhere (such as skin) is also rare
  • Poor prognosis (Am J Surg Pathol 2010:34:942)
  • Risk factors at other sites include exposure to arsenic, Thorotrast, polyvinyl chloride or radiation; also posttreatment lymphedema
Case reports
Gross images

Images hosted on PathOut server:

Multiple hemorrhagic masses

Microscopic (histologic) description
  • Infiltrative, often with extensive destruction of the parenchyma, at least small areas of vasoformative growth (Am J Surg Pathol 2010:34:942), although spindled / epithelioid growth may be prominent
Microscopic (histologic) images

Images hosted on PathOut server:

Numerous blood filled vascular spaces

Images hosted on other servers:

Anastomosing vascular channels with minimal atypia

Endothelial cells in compact sheets

Cytology description
  • Highly pleomorphic cells, some containing hemosiderin
  • Neovascular structures with intracytoplasmic lumina containing erythrocytes
  • Cells are noncohesive with long cytoplasmic processes
  • Erythrophagocytosis is present; variable cellularity due to necrosis
Cytology images

Images hosted on other servers:

50 year old man: various images

Electron microscopy description
  • Spindle cells with abundant pinocytotic vesicles, intermediate filaments, rare Weibel-Palade bodies
Differential diagnosis