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Kidney tumor - adult malignancies

Adult renal cell carcinoma

Eosinophilic variant of clear cell renal cell carcinoma


Reviewers: Sean Williamson, M.D. (see Reviewers page)
Revised: 29 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Clear cell renal cell carcinoma with prominent areas of eosinophilic cytoplasm – may mimic another subtype of renal cell carcinoma, particularly on small biopsies
● Often extensive (>50%) necrosis; higher grade and stage than other renal cell carcinomas, higher risk of progression
● “Granular cell variant” terminology is discouraged, as multiple distinct tumor subtypes may be falsely categorized together

Micro description
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● Perinuclear eosinophilia, cytoplasmic eosinophilic globules; classic clear cell areas present elsewhere

Micro images
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Figure 3

Electron microscopy description
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● Similar to classic type but with more mitochondria that are swollen and pleomorphic, rarefied matrix and attenuated cristae
● May have scant microvesicles

Additional references
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Am J Surg Pathol 2000;24:1247

End of Kidney tumor - adult malignancies > Adult renal cell carcinoma > Eosinophilic variant of clear cell renal cell carcinoma


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