Kidney tumor - adult malignancies
Adult renal cell carcinoma
Eosinophilic variant of clear cell renal cell carcinoma
Reviewers: Sean Williamson, M.D. (see Reviewers page)
Revised: 29 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Clear cell renal cell carcinoma with prominent areas of eosinophilic cytoplasm – may mimic another subtype of renal cell carcinoma, particularly on small biopsies
● Often extensive (>50%) necrosis; higher grade and stage than other renal cell carcinomas, higher risk of progression
● “Granular cell variant” terminology is discouraged, as multiple distinct tumor subtypes may be falsely categorized together
● Perinuclear eosinophilia, cytoplasmic eosinophilic globules; classic clear cell areas present elsewhere
Electron microscopy description
● Similar to classic type but with more mitochondria that are swollen and pleomorphic, rarefied matrix and attenuated cristae
● May have scant microvesicles
● Am J Surg Pathol 2000;24:1247
End of Kidney tumor - adult malignancies > Adult renal cell carcinoma > Eosinophilic variant of clear cell renal cell carcinoma
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