Kidney tumor - Adult malignancies
Other neoplasms - Adult or adult / child
Clear cell sarcoma of soft parts - Adult

Author: Sean Williamson, M.D. (see Authors page)

Revised: 7 February 2017, last major update June 2012

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PubMed Search: Clear cell sarcoma soft parts kidney

Cite this page: Clear cell sarcoma of soft parts - Adult. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantclearcellsarcomasoftparts.html. Accessed March 26th, 2017.
Definition / General
  • Also called melanoma of soft parts
  • Very rare in kidney, with only one case report
  • See also: Soft tissue chapter
Case Reports
Micro Description
  • Nests or short fascicles of spindled or epithelioid cells with clear to granular eosinophilic cytoplasm separated by fibrous septa; surrounds normal epithelial elements
  • Also multinucleated giant cells, variable melanin
Positive Stains
Negative Stains
Molecular / Cytogenetics Description
  • t(12;22)(q13;q12), EWS / ATF1 gene region rearrangement in > 95% (at other sites)
Differential Diagnosis
  • Clear cell sarcoma: very young children, similar histology but nests are formed by vascular structures, S100-, HMB45-, different translocation
  • Wilms' tumor: usually triphasic, no dominant nesting pattern, negative for melanocytic markers