Kidney tumor
Other adult malignancies
Clear cell sarcoma of soft parts - adult

Author: Sean R. Williamson, M.D.

Revised: 19 April 2018, last major update June 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Clear cell sarcoma soft parts kidney

Cite this page: Williamson, S.R. Clear cell sarcoma of soft parts - Adult. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantclearcellsarcomasoftparts.html. Accessed May 22nd, 2018.
Definition / general
  • Also called melanoma of soft parts
  • Very rare in kidney, with only one case report
  • See also: Soft tissue chapter
Case reports
Microscopic (histologic) description
  • Nests or short fascicles of spindled or epithelioid cells with clear to granular eosinophilic cytoplasm separated by fibrous septa; surrounds normal epithelial elements
  • Also multinucleated giant cells, variable melanin
Positive stains
Negative stains
Molecular / cytogenetics description
  • t(12;22)(q13;q12), EWS / ATF1 gene region rearrangement in > 95% (at other sites)
Differential diagnosis
  • Clear cell sarcoma: very young children, similar histology but nests are formed by vascular structures, S100-, HMB45-, different translocation
  • Wilms' tumor: usually triphasic, no dominant nesting pattern, negative for melanocytic markers