Kidney tumor
Miscellaneous (carcinoma)
Frozen sections / intraoperative consultations


Topic Completed: 1 September 2016

Revised: 6 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Kidney tumor frozen sections
Page views in 2018: 166
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Cite this page: Gupta P. Frozen sections / intraoperative consultations. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantfrozensections.html. Accessed March 22nd, 2019.
Definition / general
    Margins:
  • Assessment of surgical margins is often performed in partial nephrectomy cases (Urology 2006;67:923, Scand J Urol Nephrol 2005;39:222)
  • However, clinical significance may be limited, as only rare patients harbor residual disease in a follow up radical nephrectomy specimen or repeated partial resection of margin
  • Recurrence due to positive margin is uncommon (Urology 2011;77:1400, J Urol 2005;173:385)
  • Routine use is controversial due to a relatively high false negative rate, controversy over the prognosis of a positive margin and its inconsistent impact on intraoperative management (BJU Int 2015;116:868)
  • Other indications (although no consensus exists) are:
    1. Solid renal mass in a diffusely cystic kidney or other unusual setting
    2. Synchronous renal and extrarenal masses
    3. Cystic renal lesions
    4. Multiple renal masses (Arch Pathol Lab Med 2005;129:1585, J Urol 2008;179:461)
  • Cystic and spindle cell tumors are often misdiagnosed at frozen section
  • Clear cell renal cell carcinoma can be confused with inflammatory lesions, particularly those containing foamy histiocytes
Gross images

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Renal cystic tumors

Microscopic (histologic) images

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Angiomyolipoma

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Renal cystic tumors

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Clear cell renal cell carcinoma

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Urothelial, collecting duct and papillary carcinomas

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Oncocytoma and chromophobe RCC

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