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Kidney tumor - adult malignancies

Other neoplasms adult or adult/child

Hemangiopericytoma


Reviewers: Sean Williamson, M.D. (see Reviewers page)
Revised: 30 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare; <50 cases reported
● May arise in perirenal tissues or renal capsule with secondary invasion of kidney

Epidemiology
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● Often older patients; may be associated with hypoglycemia

Case reports
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● 15 year old boy with tumor of renal pelvis (Urology 2007;70:811e13)
● 43 year old woman (Urology 2008;71:755)
● 50 year old man (Internet Journal of Urology 2008;5(2))
● Bilateral metastases to kidney from CNS primary (Int Braz J Urol 2006;32:306)

Gross description
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● Large circumscribed tumor

Gross images
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Well circumscribed tumor with cystic and hemorrhagic areas

Micro description
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● Rich network of branching vessels with staghorn configuration, lined by single layer of endothelium, surrounded by haphazard pattern of round/oval tumor cells with indistinct cell borders

Micro images
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H&E and silver stain


Not kidney: uniform neoplastic cells around branched, thin-walled, staghorn vascular spaces

Cytology description
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● Cellular, single and tightly packed clusters of oval to spindled cells aggregated around branched capillaries
● Usually basement membrane material
● Nuclei are uniform and oval with finely granular chromatin and inconspicuous nucleoli
● No mitotic figures, no necrosis (Cancer 1999;87:190)

Cytology images
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Not necessarily kidney:

Irregular fragments of tissue, loose cellular aggregates and single cells (Diff-Quik)


Uniform oval or spindled cells with high N/C ratio and indistinct borders plus endothelial-lined capillary vessels (Diff-Quik)


Metachromatic basement membrane material separates tumor cells from endothelial cells (Diff-Quik)

End of Kidney tumor - adult malignancies > Adult renal cell carcinoma > Hemangiopericytoma


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