Kidney tumor - Adult malignancies
Other neoplasms - Adult or adult / child
Lymphoma

Author: Sean Williamson, M.D. (see Authors page)

Revised: 9 February 2017, last major update July 2012

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: "renal lymphoma" kidney

Cite this page: Lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantlymphoma.html. Accessed October 17th, 2017.
Definition / general
  • Less than 1% of renal tumors
Clinical features
  • More often secondary involvement than primary; usually bilateral, usually B cell
  • Diffuse large cell lymphoma is most common subtype
  • High rate of CNS relapse in patients with kidney involvement by diffuse large B cell lymphoma (Haematologica 2011;96:1002)
  • FNA usually conclusive but high index of suspicion is important for a correct interpretation (Am J Clin Pathol 2001;115:18)
  • May occur in transplanted kidney (Clin Transplant 2008;22:512)
Radiology images

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PET / CT showing bilateral kidneys

CT of large B cell lymphoma

Case reports
Diffuse large B cell lymphoma / intravascular lymphoma:
Intravascular T cell lymphoma:
MALT lymphoma:
Other:
Gross images

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Massive tumor

Main tumor in hilar region



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Diffuse large B cell lymphoma

Microscopic (histologic) description
  • Glomeruli and other structures are usually intact
Microscopic (histologic) images

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Diffuse large B cell



Angiocentric T cell lymphoma:

Massive lymphoid infiltrate

Mixed inflammatory cell population



Case of the Week #126:

CD10

CD34

CD79a

TdT


Core biopsy

Bone marrow



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Burkitt-like lymphoma

MALT images

SLL / CLL in cyst

Intravascular diffuse large B cell



Case reports, 77 year old woman:

Fig. 1B: renal cell carcinoma (large arrows), intravascular lymphoma (small arrows);
Fig. 1C: intravascular lymphoma;
Fig. 1D: CD20+ (B cell)



72 year old man:

Fig 1: hypercellular glomeruli due to atypical mononuclear cells;
Fig 2: cells have irregular nuclei, occasional multiple nucleoli, mitotic figures (arrow);
Fig 3A: CD20+; Fig 3B: CD3 negative; Fig 3C: bcl2+; Fig 3D: CD68 negative;
Fig 4: EM shows focal foot process fusion (arrowheads) and microvillous transformation,
also abundant endoplasmic reticulum (arrow)

Positive stains
Cytology images

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Burkitt lymphoma

HIV+ patient

Additional references