Kidney tumor - adult malignancies
Other neoplasms – adult or adult/child
Metanephric / mesonephric adenosarcoma
Reviewers: Sean Williamson, M.D. (see Reviewers page)
Revised: 4 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Very rare tumors with sarcomatous stroma and benign epithelium
● Initial case described had rhabdomyoblastic differentiation (Am J Surg Pathol 1985;9:610)
● 21 year old woman with metanephric adenoma mixed with a malignant spindle cell component (Am J Surg Pathol 2001;25:1451)
● 56 year old woman (Pathol Int 2011;61:313)
● Separate but contiguous or intimately mingled epithelial and stromal components
● Epithelium: small cuboidal cells with scant cytoplasm, forming papillary projections, tubules, acini, solid-appearing areas, psammoma bodies, glomeruloid papillae (absence of necrosis/mitotic figures)
● Stroma: spindle cell proliferation with high mitotic rate and necrosis
● Cytokeratin (AE1/AE3), vimentin
● EMA, NSE
● Metanephric adenofibroma: stroma composed of benign fibroblast-like cells without significant atypia, increased mitotic rate or necrosis
● Mesoblastic nephroma: smooth muscle differentiation in stromal component
● Papillary renal cell carcinoma (with sarcomatoid component): cytokeratin 7 and EMA frequently positive, transition areas frequently present, chromosome 7 and 17 abnormalities
End of Kidney tumor - adult malignancies > Adult renal cell carcinoma > Metanephric / mesonephric adenosarcoma
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