Kidney tumor
Other adult malignancies
Post kidney transplant tumors

Author: Sean Williamson, M.D., Mandolin Ziadie, M.D. (see Authors page)

Revised: 9 February 2017, last major update July 2012

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PubMed Search: "Post kidney transplant" tumors

Cite this page: Post kidney transplant tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantposttransplanttumors.html. Accessed October 18th, 2017.
Definition / general
Most Common Post Kidney Transplant Malignancies
  • Italian study: viral related - Kaposi sarcoma and EBV+ non-Hodgkin lymphoma, with common sites being native kidney, uterus and liver (Epidemiol Prev 2008;32:205)
  • Thailand study: urothelial and hepatocellular carcinomas (Transplant Proc 2008;40:2403)
  • Korean study: stomach cancer, 10× risk of these tumors - Kaposi sarcoma, lymphoma, skin cancer, cervical, renal cell carcinoma (Transpl Int 2011;24:716)
  • National Cancer Institute study (kidney plus other solid organ recipients): most common malignancies are non-Hodgkin lymphoma, lung (1.46 SIR in kidney recipients), kidney (6.66 SIR in kidney recipients, JAMA 2011;306:1891)

Hodgkin lymphoma:
Non-Hodgkin lymphoma:
  • Well recognized risk posttransplant, usually EBV associated extranodal B cell lymphomas that respond to reduction of immunosuppressive treatment
  • EBV promotes proliferation of B cells, which may escape T cell control

Posttransplant lymphoproliferative disorders:
  • Plasmacytic and polymorphic B cell hyperplasias are not monoclonal by flow cytometry
  • Most B cell lymphomas or myelomas are clonal by flow cytometry, even if genotypic studies are negative (Am J Clin Pathol 2002;117:24)

Skin cancer:
Post kidney transplant tumors (not in kidney):
Treatment
  • Reduction in immunosuppression usually not sufficient for tumors in general, also need chemotherapy (Acta Haematol 2008;120:36)
Microscopic (histologic) images

Images hosted on other servers:

Hodgkin lymphoma

Posttransplant hemolytic uremic syndrome

Diffuse large B cell lymphoma

Membranous glomerulonephritis post kidney transplantation

Atypical lymphoid cells
with posttransplant
lymphoproliferative
disease (PTLD)