Kidney tumor - adult malignancies
Adult renal cell carcinoma
Primary thyroid-like follicular carcinoma

Author: Sean Williamson, M.D. (see Authors page)

Revised: 1 February 2017, last major update June 2012

Copyright: (c) 2003-2017,, Inc.

PubMed Search: Primary thyroid-like follicular carcinoma

Cite this page: Primary thyroid-like follicular carcinoma. website. Accessed February 21st, 2018.
Definition / general
  • Kidney tumor that mimics well differentiated thyroid follicular neoplasm
  • No gender preference, age range of 29 - 83 years
Clinical features
Case reports
Gross description
  • 2 - 4 cm, encapsulated
Microscopic (histologic) description
  • Follicular architecture with micro and macrofollicles containing inspissated colloid-like material
  • May have focal tightly packed follicles without secretions
  • Follicular cells have moderate amphophilic to eosinophilic cytoplasm, round nuclei, occasional prominent nucleoli
Negative stains
Molecular / cytogenetics description
  • Gene expression profile is distinct from clear cell or chromophobe renal cell carcinoma
Differential diagnosis
  • Carcinoid tumor: rare, patterns are insular, cords, nests or ribbons but not follicular; neuroendocrine histology, synaptophysin+, chromogranin+
  • Metastatic follicular carcinoma arising in struma ovarii in females
  • Metastatic thyroid carcinoma: very rare to kidney, usually obvious thyroid primary with widely disseminated metastases, thyroglobulin+ or TTF1+