Kidney tumor - adult malignancies
Renal pelvic tumors
Adenocarcinoma of renal pelvis

Authors: Sean Williamson, M.D. (see Authors page)

Revised: 11 August 2016, last major update June 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Adenocarcinoma of renal pelvis
Definition / General
  • Rare neoplasm (1%) of renal pelvis originating from urothelium with pure glandular differentiation
Epidemiology
  • Most primary renal neoplasms of renal pelvis are urothelial carcinomas; urothelial carcinoma with glandular differentiation is more common than pure adenocarcinoma
  • A link between adenocarcinoma and pyelitis glandularis / pyelitis cystica, secondary to chronic inflammation or renal stones, is controversial (Urology 2008;71:915, Clin Cancer Res 2007;13:6232)
Case Reports
Gross Description
  • Large, infiltrating tumor, which fills dilated renal pelvis and calyces and invades adjacent renal parenchyma
Gross Images

Images hosted on PathOut server:

Case of the Week #397 - horseshoe kidney with papillary mucinous cystadenocarcinoma of renal pelvis:

Atrophic, hydronephrotic kidney parenchyma with renal pelvis cyst

Close-up of opened renal pelvis cyst

Cyst wall section showing papillary projections



Case of the Week #94 - signet ring cell adenocarcinoma:

Various images

Micro Description
Micro Images

Images hosted on PathOut server:

Case of the Week #397 - horseshoe kidney with papillary mucinous cystadenocarcinoma of renal pelvis:

Cyst wall (4x)

Background renal parenchyma (10x)

Cyst lining (10x)

Cyst wall (10x)

Cyst lining (20x)

Mucin (10x)



Case of the Week #94 - signet ring cell adenocarcinoma:

Rhabdoid features and intracytoplasmic lumina

Signet ring cells

Superficial invasion by tumor cells

With goblet cell metaplasia

Mucin+ with PAS-Alcian Blue stain

Positive Stains
Differential Diagnosis
  • Urothelial carcinoma with glandular differentiation: shows admixture of typical urothelial carcinoma and glandular component
  • Metastasis or direct extension: exclusion is critical (colorectal, stomach, breast, or others)