Kidney tumor
Renal pelvis
Adenocarcinoma of renal pelvis


Topic Completed: 1 June 2012

Revised: 16 September 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Adenocarcinoma renal pelvis [title] kidney

Sean R. Williamson, M.D.
Page views in 2018: 829
Page views in 2019 to date: 681
Cite this page: Williamson SR. Adenocarcinoma of renal pelvis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantrenaladenoca.html. Accessed October 22nd, 2019.
Definition / general
  • Rare neoplasm (1%) of renal pelvis originating from urothelium with pure glandular differentiation
Epidemiology
  • Most primary renal neoplasms of renal pelvis are urothelial carcinomas; urothelial carcinoma with glandular differentiation is more common than pure adenocarcinoma
  • A link between adenocarcinoma and pyelitis glandularis / pyelitis cystica, secondary to chronic inflammation or renal stones, is controversial (Urology 2008;71:915, Clin Cancer Res 2007;13:6232)
Case reports
Gross description
  • Large, infiltrating tumor, which fills dilated renal pelvis and calyces and invades adjacent renal parenchyma
Gross images

Case of the Week #397 - Horseshoe kidney with papillary mucinous cystadenocarcinoma of renal pelvis

Close up of opened renal pelvis cyst

Cyst wall section showing papillary projections

Atrophic, hydronephrotic
kidney parenchyma
with renal pelvis cyst



Case of the Week #94 - Signet ring cell adenocarcinoma

Various images

Microscopic (histologic) description
Microscopic (histologic) images

Case of the Week #397 - Horseshoe kidney with papillary mucinous cystadenocarcinoma of renal pelvis

Cyst wall (4×)

Background renal parenchyma (10×)

Cyst lining (10×)

Cyst wall (10×)

Mucin (10×)

Cyst lining (20×)



Case of the Week #94 - Signet ring cell adenocarcinoma

Rhabdoid features and intracytoplasmic lumina

Signet ring cells

Superficial invasion by tumor cells

With goblet cell metaplasia

Mucin+ with PAS Alcian blue stain

Positive stains
Differential diagnosis
  • Metastasis or direct extension: exclusion is critical (colorectal, stomach, breast or others)
  • Urothelial carcinoma with glandular differentiation: shows admixture of typical urothelial carcinoma and glandular component
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