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Kidney tumor - adult malignancies

Adult renal cell carcinoma

Squamous cell carcinoma of kidney


Reviewers: Sean Williamson, M.D. (see Reviewers page)
Revised: 29 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Associated with squamous metaplasia of renal pelvis, renal calculi or infection (J Urol 2010;183:2023)
● Cases with associated urothelial carcinoma or urothelial carcinoma in situ are best classified as urothelial carcinoma with squamous differentiation
● Usually advanced at diagnosis; poor prognosis (J Urol 2007;178:51)
Origin: Hypothesized to originate from squamous metaplasia in response to chronic irritation

Epidemiology
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● Approximately equal men and women, age 50-70 years (J Urol 2007;178:51)

Clinical description
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● Hematuria, abdominal pain, flank pain
● May produce paraneoplastic syndrome, similar to squamous carcinoma of lung

Case reports
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● With carcinosarcoma (Pathol Res Pract 2003;199:48)
● Renal pelvis tumor after radiotherapy for seminoma (Urology 2007;70:812.e3)
● Arising in horseshoe kidney (Urology 2011;78:54)

Gross description
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● Large, necrotic, ulcerated tumor

Gross images
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Squamous carcinoma and chromophobe carcinoma


Metastatic from lung primary

Micro description
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● Resembles squamous cell carcinoma of other organs
● Infiltrating nests of atypical squamous epithelial cells with or without keratinization; a component of typical urothelial carcinoma is absent

Micro images
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Invasive tumor with overlying squamous metaplasia of urothelium

       
Moderately differentiated tumor with keratin pearls


Squamous and chromophobe carcinoma

Metastases to kidney:

Metastatic tumor occludes the lumen of the renal artery


Squamous cell nature of the tumor is evident

Differential diagnosis
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● Urothelial carcinoma with squamous differentiation: other areas of urothelial carcinoma evident on thorough sectioning

End of Kidney tumor - adult malignancies > Adult renal cell carcinoma > Squamous cell carcinoma of kidney


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