Kidney tumor
Renal pelvis: Urothelial carcinoma and variants
Urothelial carcinoma of renal pelvis, with glandular differentiation


Topic Completed: 1 January 2016

Revised: 18 September 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Urothelial carcinoma glandular differentiation renal pelvis

Related Topic: Urothelial carcinoma of renal pelvis

Nicole K. Andeen, M.D.
Maria Tretiakova, M.D., Ph.D.
Page views in 2018: 138
Page views in 2019 to date: 142
Cite this page: Andeen NK, Tretiakova M. Urothelial carcinoma of renal pelvis, with glandular differentiation. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignanturothelialcarcinomasubtypesglandulardiff.html. Accessed November 16th, 2019.
Definition / general
  • Glandular differentiation is defined by the presence of true glandular spaces, usually tubular or gland-like lumina, or with morphology similar to enteric adenocarcinomas and variable mucin production
  • Cytoplasmic mucin containing cells are seen in normal urothelium and are not considered to represent glandular differentiation (Arch Pathol Lab Med 2007;131:1244)
Essential features
  • Presence of true glandular spaces
    • Cytoplasmic mucin is seen in normal urothelium and not diagnostic of glandular differentiation
  • No known prognostic significance
Epidemiology
  • Foci of glandular differentiation are less common than squamous differentiation, and seen in up to 10% of urothelial carcinomas (Mod Pathol 2009;22:S96)
Sites
  • Bladder, kidney
Clinical features
  • Similar to other urothelial carcinomas
Prognostic factors
Case reports
Treatment
  • Too few cases to establish specific treatment recommendations
Microscopic (histologic) description
  • True glandular structures within a conventional urothelial carcinoma
  • Glands are of either tubular or enteric type, with a single layer of neoplastic columnar cells radially arranged around a lumen, with or without mucin production
  • May resemble enteric adenocarcinomas
  • May have signet ring morphology, with neoplastic signet ring cells floating in pools of mucin
Microscopic (histologic) images

Contributed by Nicole K. Andeen, M.D. and Maria Tretiakova, M.D., Ph.D.

Various images



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Gland-like lumina

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Irregular branching lumina

Differential diagnosis
Additional references
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