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Kidney tumor - cysts, children, adult benign

Childhood neoplasms

Oncocytoid renal cell carcinoma after neuroblastoma


Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 2 January 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Described in one series (Am J Surg Pathol 1999;23:772) with similar tumor described after treatment for cardiac leiomyosarcoma (Urology 2007;70:178.e13)

Clinical features
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● 4 cases described with mean age 9 years, range 5-13 years
● Mean interval between neuroblastoma and carcinoma of 7 years (range 3-12 years)

Micro description
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● Expansile masses of large cells with well defined cell membranes
● Abundant eosinophilic, oncocytic or reticular cytoplasm
● Enlarged nuclei with mildly irregular contours, distinct nucleoli
● Occasional lipid-laden histiocytes, psammoma bodies and mitotic figures
● Cells arranged in solid and papillary patterns
● May resemble high grade papillary renal cell carcinoma, but predominantly solid and without necrosis

Micro images
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Various images

Positive stains
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● EMA, vimentin, CK8, CK18 and variable CK 20

Negative stains
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● HMB45, S100 and CK7

Molecular description
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● 14q31 and 20q13 abnormalities
● Also other changes not typical for renal cell carcinoma

EM description
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● Microvilli and cell junctions, less mitochondria than oncocytoma
● No microvesicles

End of Kidney tumor - cysts, children, adult benign > Childhood neoplasms > Oncocytoid renal cell carcinoma after neuroblastoma


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