Kidney tumor
Benign adult tumors

Topic Completed: 1 February 2012

Minor changes: 27 September 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Oncocytosis kidney

Mandolin S. Ziadie, M.D.
Page views in 2019: 616
Page views in 2020 to date: 292
Cite this page: Ziadie MS. Oncocytosis. website. Accessed May 26th, 2020.
Definition / general
  • Rare diffuse renal involvement by numerous oncocytic lesions without necrosis
  • Often associated with at least 1 dominant nodule (2 - 10 cm), usually an oncocytoma, chromophobe carcinoma or hybrid; recent study suggests neoplasms are distinct from oncocytoma or chromophobe carcinoma (Am J Surg Pathol 2010;34:620)
  • 43% bilateral; may be hemorrhagic
  • Associated with chronic kidney disease (J Urol 2011;185:795)
  • The coexistence of oncocytosis and chromophobe renal carcinoma suggests that these two lesions are related and part of a spectrum of oncocytic disease
Case reports
Gross description
  • Well circumscribed, unencapsulated and solid lesion with a homogenous mahogany or yellowish brown cut surface
Gross images

AFIP images

Kidney contained nine discrete tumors

Images hosted on other servers:

Bilateral renal oncocytosis

Microscopic (histologic) description
  • Multiple oncocytic nodules, often hybrid nodules with chromophobe carcinoma
  • An interstitial pattern (oncocytes infiltrate between benign glomeruli and tubules), diffuse oncocytic change in nonneoplastic tubules and benign oncocytic cortical cysts may also be present
Microscopic (histologic) images

Images hosted on other servers:

Various images

Additional references
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