Kidney tumor
Benign (usually) adult tumors

Author: Mandolin Ziadie, M.D.

Revised: 18 April 2018, last major update February 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Oncocytosis kidney

Cite this page: Ziadie, M.S. Oncocytosis. website. Accessed June 19th, 2018.
Definition / general
  • Rare diffuse renal involvement by numerous oncocytic lesions without necrosis
  • Often associated with at least 1 dominant nodule (2 - 10 cm), usually an oncocytoma, chromophobe carcinoma or hybrid; recent study suggests neoplasms are distinct from oncocytoma or chromophobe carcinoma (Am J Surg Pathol 2010;34:620)
  • 43% bilateral; may be hemorrhagic
  • Associated with chronic kidney disease (J Urol 2011;185:795)
  • The coexistence of oncocytosis and chromophobe renal carcinoma suggests that these two lesions are related and part of a spectrum of oncocytic disease
Case reports
Gross description
  • Well circumscribed, unencapsulated and solid lesion with a homogenous mahogany or yellowish brown cut surface
Gross images

Images hosted on PathOut server:

Kidney contained nine discrete tumors

Images hosted on other servers:

Bilateral renal oncocytosis

Microscopic (histologic) description
  • Multiple oncocytic nodules, often hybrid nodules with chromophobe carcinoma
  • An interstitial pattern (oncocytes infiltrate between benign glomeruli and tubules), diffuse oncocytic change in nonneoplastic tubules and benign oncocytic cortical cysts may also be present
Microscopic (histologic) images

Images hosted on other servers:

Various images

Additional references