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Kidney tumor - cysts, children, adult benign

Benign (usually) adult tumors

Oncocytosis


Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 29 March 2012, last major update February 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare diffuse renal involvement by numerous oncocytic lesions without necrosis
● Often associated with at least 1 dominant nodule (2-10 cm), usually an oncocytoma, chromophobe carcinoma or hybrid; recent study suggests neoplasms are distinct from oncocytoma or chromophobe carcinoma (Am J Surg Pathol 2010;34:620)
● 43% bilateral; may be hemorrhagic
● Associated with chronic kidney disease (J Urol 2011;185:795)

Pathophysiology
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● The co-existence of oncocytosis and chromophobe renal carcinoma suggests that these two lesions are related and part of a spectrum of oncocytic disease

Case reports
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● 45 year old woman with 11 tumors, all with normal appearing chromosomes (Mod Pathol 2008;21:498)
● 53 year old with > 100 tumors causing end stage renal disease (Arch Pathol Lab Med 2001;125:683)

Gross description
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● Well circumscribed, unencapsulated and solid lesion with a homogenous mahogany or yellow-brown cut surface

Gross images
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Bilateral renal oncocytosis


Kidney contained nine discrete tumors

Micro description
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● Multiple oncocytic nodules, often hybrid nodules with chromophobe carcinoma
● An interstitial pattern (oncocytes infiltrate between benign glomeruli and tubules), diffuse oncocytic change in non-neoplastic tubules and benign oncocytic cortical cysts may also be present

Micro images
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Various images

Additional references
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Am J Surg Pathol 1999;23:1094

End of Kidney tumor - cysts, children, adult benign > Benign (usually) adult tumors > Oncocytosis


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