Kidney tumor - adult malignancies
Benign (usually) adult tumors
Perineurioma

Author: Pallav Gupta, M.D. (see Authors page)

Revised: 7 March 2016, last major update March 2016

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Perineurioma [title] kidney
Definition / General
  • Rare benign tumor of perineurial cells, either intraneural or perineural
  • Extraneural perinerioma is seen in soft tissue, head and neck, brain, kidney, intestines
Essential Features
  • Spindle shaped cells with elongated cytoplasmic processes and wavy nuclei
  • EMA+, S100-
Case Reports
Gross Description
  • Usually unencapsulated, circumscribed, firm and grey white on cut surface
Micro Description
  • Spindle cells with elongated processes, indistinct cell boundaries and wavy nuclei
  • Intercellular matrix can be abundant or scanty
  • Stroma can be collagenous or myxoid
  • Usually no mitotic figures, no necrosis
  • Micro Images

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    Perineurioma, site unspecified

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    Extraneural soft tissue perineurioma

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    Sclerosing perineurioma

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    Reticular perineurioma

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    Intraneural perineurioma

    Positive Stains
    Negative Stains
    Differential Diagnosis
    • DFSP: storiform pattern, infiltrative growth, EMA-
    • Fibromatosis: spindle cells in long fascicles, cells have tapering or plump vesicular nuclei, dense collagenous matrix, infiltrative growth pattern, slit like vessels, SMA+
    • Low grade fibromyxoid sarcoma: focal to diffuse whorling, heavily collagenized stroma with abrupt transition to myxoid areas, often epithelioid areas, large collagen rosettes and infiltration of adjacent tissue
    • Schwannoma: Antoni A and Antoni B areas, long fascicles, Verocay bodies, ectatic blood vessels, S100+, EMA-, type 4 collagen-
    • Smooth muscle tumors: intersecting fascicles, abundant eosinophilic cytoplasm with cigar shaped nuclei with blunt ends, SMA+, desmin+
    • Solitary fibrous tumor: patternless (may have focal storiform pattern) with dense collagen bundles, hyalinized vessels, staghorn vessels, EMA+, CD34+
    Additional References