Kidney tumor - cysts, children, adult benign
Childhood neoplasms
Rhabdoid tumor

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 17 January 2017, last major update January 2012

Copyright: (c) 2003-2017,, Inc.

PubMed Search: Rhabdoid tumor [title] kidney

Cite this page: Rhabdoid tumor. website. Accessed April 27th, 2017.
Definition / General
  • Highly aggressive renal tumor of infancy
  • 1% - 2% of childhood renal tumors
  • 60% are < 1 year old, 30% are 1 - 3 years old, rare > 5 years
  • 15% are associated with PNET in the midline posterior fossa
Diagrams / Tables

Images hosted on PathOut server:

Age distribution

Clinical Features
  • Very aggressive; 82% present with metastases; 90% die in 2 years
  • Usually stage 2 or higher; 9% are bilateral
Case Reports
Gross Description
  • Small, fleshy / hemorrhagic tumor with ill defined margins involves medullary region
  • Satellite lesions may be present
Gross Images

Images hosted on PathOut server:

Soft tan tumor

Images hosted on other servers:

round lobulated mass (fig 14)

Micro Description
  • Diffuse sheets, trabecula or alveolar pattern of large monomorphic cells with well defined cell borders
  • Aggressive invasive patern
  • Neoplastic cells have pink cytoplasm with eccentric nuclei due to intracytoplasmic inclusions of eosinophilic hyaline globules
  • Chromatin is clear / vesicular with central, large nucleoli
  • Occasionally cells are spindled; variable necrosis and mitoses
Micro Images

Images hosted on PathOut server:

High grade tumor with abundant cytoplasm, perinuclear inclusions and prominent nucleoli

Rhabdoid tumor

Sheets of tumor cells surround glomerulus

Patterns (left to right): epithelioid, hyalinizing, chondroid

Images hosted on other servers:

38 year old woman - various images

10 year old girl
Fig 1: CT shows large calcified mass in pelvic brim
fig 2 / 3: nodules of large, cells with well defined cell borders,
abundant eosinophilic cytoplasm pushing nuclei to periphery,
karyotype shows +X, +2 +7 plus other changes

Rhabdoid and medullary tumors, H&E and INI1

Positive Stains
Negative Stains
Electron Microscopy Description
  • Hyaline globules composed of tangled intermediate filaments
Molecular / Cytogenetics Description
Differential Diagnosis
Additional References