Kidney tumor
Benign (usually) adult tumors
Sinus histiocytosis with massive lymphadenopathy

Author: Mandolin Ziadie, M.D.

Revised: 18 April 2018, last major update March 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Sinus histiocytosis massive lymphadenopathy kidney

Cite this page: Ziadie, M.S. Sinus histiocytosis with massive lymphadenopathy. website. Accessed October 20th, 2018.
Definition / general
  • Rare disease with even rarer involvement of kidney
  • More common in children and young adults
Clinical features
  • Fever, leukocytosis, anemia, elevated sedimentation rate and polyclonal hypergammaglobulinemia
  • Relatively favorable prognosis
  • Poor prognostic factors include multiple organ involvement, disseminated nodal disease and systemic immunologic disorder
Case reports
Gross description
  • Pelvic / sinus mass with multinodular, tanish yellow or gray hemorrhagic cut surface (may appear similar to renal cell carcinoma)
Gross images

Images hosted on other servers:

Well circumscribed mass
with a creamy brownish

Microscopic (histologic) description
  • Tissue infiltration by sheets of large histiocytes with granular eosinophilic cytoplasm, large, round and vesicular nuclei, prominent nucleoli and accompanied by plasma cells and lymphocytes
  • Extensive emperipolesis (histiocytes with intracytoplasmic lymphocytes)
Microscopic (histologic) images

Images hosted on other servers:

Emperipolesis in various disorders

Various images


Lymphoid infiltrate surrounding
scattered large histiocytic cells
containing phagocytosed intracytoplasmic
lymphocytes (arrows)

Positive stains
Negative stains