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Kidney non-tumor

Tubular and interstitial diseases

Urate nephropathy

Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 25 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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Three types:
● Acute uric acid nephropathy due to precipitation of uric acid crystals in tubules, causing acute renal failure; associated with chemotherapy for leukemia / lymphoma
● Chronic urate nephropathy, associated with gout and lead exposure from drinking “moonshine”
● Uric acid stones, in 22% with gout and 42% with secondary hyperuricemia

● Gout causes deposition of monosodium urate crystals with tophus formation that obstructs tubules, leading to cortical atrophy and scarring (eMedicine)
● Kidney injury molecule-1 expression identifies proximal tubular injury in urate nephropathy (Ann Clin Lab Sci 2008;38:210)

Gross images
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Chronic urate nephropathy


Uric acid stones

Micro images
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Gouty nephropathy

End of Kidney non-tumor > Tubular and interstitial diseases > Urate nephropathy

Ref Updated: 8/21/12

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