Kidney nontumor
Infection
Bacterial
Xanthogranulomatous pyelonephritis


Topic Completed: 4 August 2014

Minor changes: 18 February 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Xanthogranulomatous pyelonephritis

Nikhil Sangle, M.D.
Page views in 2019: 5,754
Page views in 2020 to date: 3,595
Cite this page: Sangle N. Xanthogranulomatous pyelonephritis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneyxantho.html. Accessed August 14th, 2020.
Definition / general
Clinical features
  • Destructive inflammatory process that may complicate chronic pyelonephritis
  • Usually unilateral, ages 40+, 2/3 women
  • Associated with pelvicalyceal obstruction and ulceration
  • Rarely coexists with squamous cell carcinoma (J Cancer Res Ther 2010;6:339), renal cell carcinoma (ScientificWorldJournal 2009;9:5)
Case reports
Gross description
  • Multiple yellow nodules around calyces, may form a mass and be infiltrative
Gross images

Images hosted on other servers:
Missing Image Missing Image Missing Image

Various images

Microscopic (histologic) description
  • Replacement of renal parenchyma with CD68+ foamy histiocytes, occasional multinucleated giant cells and inflammatory cells
Microscopic (histologic) images

Case of the Week #323
Missing Image Missing Image Missing Image Missing Image Missing Image Missing Image

Various images


Missing Image

CD68



Images hosted on other servers:
Missing Image Missing Image Missing Image Missing Image

Various images

Missing Image Missing Image

Liesegang rings

Differential diagnosis
  • Malakoplakia: Michaelis-Gutmann bodies
  • Renal clear cell carcinoma: Cells with clear cytoplasm may resemble histiocytes, but are keratin+, CD68-; arranged in compact, tubulocystic, alveolar or rarely papillary patterns; often glassy hyaline globules; usually nuclear grade 2 or higher; chicken wire / delicate vasculature is common (sinusoids near each packet of cells)
  • Renal replacement lipomatosis: atrophic renal parenchyma is replaced by fatty tissue, not xanthoma cells (Rev Assoc Med Bras 2011;57:262)
Back to top