Larynx, hypopharynx & trachea
Squamous cell carcinoma
Basaloid squamous cell carcinoma

Topic Completed: 1 November 2013

Minor changes: 30 September 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Basaloid squamous cell carcinoma larynx

Nat Pernick, M.D.
Page views in 2019: 1,197
Page views in 2020 to date: 875
Cite this page: Pernick N. Basaloid squamous cell carcinoma. website. Accessed August 10th, 2020.
Definition / general
  • Highly malignant, median survival 18 months (for all sites in head and neck)
  • Heavy smokers or drinkers, often with advanced disease at diagnosis and other primary tumors in the area
  • Usually men, ages 50+ years
  • Usually base of tongue, hypopharynx or supraglottic larynx
Case reports
  • Radical surgical excision, radical neck dissection and supplemental radiochemotherapy
Gross description
  • Firm to hard, tan-white masses, may have central necrosis and up to 6 cm
Microscopic (histologic) description
  • Typical areas of squamous cell carcinoma (invasive and in situ) with nests or cords of small crowded cells with minimal cytoplasm, hyperchromatic nuclei, comedonecrosis, prominent hyalinization and peripheral palisading, small cystic spaces and mitotic activity
Positive stains
Electron microscopy description
  • Rare tonofilaments, variable desmosomes
Differential diagnosis
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