Larynx and hypopharynx
Benign tumors
Giant cell tumor

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 March 2018, last major update November 2013

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Giant cell tumor larynx

Cite this page: Pernick, N. Giant cell tumor. website. Accessed March 21st, 2018.
Definition / general
  • Rare; < 50 cases reported
  • Benign but can invade into vital structures or cause airway obstruction
  • Usually involves thyroid cartilage in areas of enchondral ossification with extension into adjacent structures
Case reports
  • Excision; no recurrences reported
Microscopic (histologic) description
  • Numerous multinucleated osteoclast-like giant cells within cellular and vascular stroma containing plump, oval mononuclear cells with nuclei similar to giant cells
  • Expansile and infiltrative growth; frequent mitotic figures; often secondary cystic degeneration, reactive bone formation; no cytologic atypia
Differential diagnosis
Additional references