Larynx & hypopharynx
Benign tumors / nonneoplastic
Giant cell tumor

Topic Completed: 1 November 2013

Minor changes: 7 June 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Giant cell tumor larynx

Nat Pernick, M.D.
Page views in 2019: 431
Page views in 2020 to date: 280
Cite this page: Pernick N. Giant cell tumor. website. Accessed May 24th, 2020.
Definition / general
  • Rare; < 50 cases reported
  • Benign but can invade into vital structures or cause airway obstruction
  • Usually involves thyroid cartilage in areas of enchondral ossification with extension into adjacent structures
Case reports
  • Excision; no recurrences reported
Microscopic (histologic) description
  • Numerous multinucleated osteoclast-like giant cells within cellular and vascular stroma containing plump, oval mononuclear cells with nuclei similar to giant cells
  • Expansile and infiltrative growth; frequent mitotic figures; often secondary cystic degeneration, reactive bone formation; no cytologic atypia
Differential diagnosis
Additional references
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