Larynx & hypopharynx
Precursor epithelial lesions

Topic Completed: 1 November 2013

Minor changes: 7 June 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Hyperplasia [title] larynx [title]

Nat Pernick, M.D.
Page views in 2019: 1,480
Page views in 2020 to date: 493
Cite this page: Pernick N. Hyperplasia. website. Accessed May 26th, 2020.
Definition / general
  • Also called keratosis
  • Usually involves true vocal cords and interarytenoid area
  • Associated with smokers, singers and others who use voices excessively
Gross description
  • White thickening of involved areas
  • Verrucous keratosis if undulating warty configuration
  • Pachyderma larynges if extensive keratinization
Microscopic (histologic) description
  • When in respiratory (ciliated columnar) epithelium (false cord, ventricle, subglottic region), initially hyperplasia of reserve cells under epithelium, then replacement of epithelium by full thickness reserve cells, then complete squamous metaplasia; may have hyperkeratotic epithelium
  • No nuclear abnormalities are present but underlying submucosal glands persist
  • Pseudoepitheliomatous hyperplasia: exuberant reactive overgrowth of squamous epithelium without atypia; may resemble invasive squamous cell carcinoma
Differential diagnosis
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